Anti-IL7R Antibody Prodrug, Protease Activated (VS-1025-YC74)

Name: Anti-IL7R Antibody Prodrug, Protease Activated (VS-1025-YC74)
SKU: VS-1025-YC74
Rating: 5 (1 reviews)

CAT#: VS-1025-YC74

The Anti-IL7R Antibody Prodrug, Protease Activated (VS-1025-YC74) is an antibody prodrug comprised of a recombinant human antibody targeting human IL7R, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to IL7R protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to IL7R effectively. IL7R (Interleukin-7 Receptor) is a cytokine receptor whose signaling is essential for normal T- and B-cell development. Activating mutations in IL7R are a significant oncogenic driver in a subset of T-cell Acute Lymphoblastic Leukemia (T-ALL), causing ligand-independent activation of the JAK/STAT pathway and driving the relentless proliferation of the leukemic cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67550/1779_G6_3_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & centriolar satellites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/209_B7_2_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/210_B7_2_blue_red_green.jpg

Subcellular Location Figure 4 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to Centriolar satellite.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10215/211_B7_2_blue_red_green.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, fHDF/TERT166, HBF TERT88, REH)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168685-IL7R

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Specifications

Host Animal
Human

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human IL7R

Target
IL7R

Species Reactivity
Human

Isotype
IgG

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.

Alternative Names
ILRA; CD127; IL7RA; CDW127; IL-7R-alpha

Gene ID
3575

UniProt ID
P16871

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Datasheet

Datasheet - VS-1025-YC74.pdf

MSDS

MSDS - VS-1025-YC74.pdf

COA

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