Recombinant Anti-INSR (AA 191-290 x AA 485-592) Biparatopic Antibody, Tandem scFv (Clone IR 18-146 x Clone IR 47-46)

Name: Recombinant Anti-INSR (AA 191-290 x AA 485-592) Biparatopic Antibody, Tandem scFv (Clone IR 18-146 x Clone IR 47-46)
SKU: VS-0525-YC114
Rating: 5 (1 reviews)

CAT#: VS-0525-YC114

The Recombinant Anti-INSR (AA 191-290 x AA 485-592) Biparatopic Antibody, Tandem scFv (Clone IR 18-146 x Clone IR 47-46) is a biparatopic antibody (bpAb) designed for dual epitope binding on INSR. The bpAb's tandem scFv structure comprises the IR 18-146 scFv (specific for amino acids 191-290 of INSR) N-terminally fused to the IR 47-46 scFv (targeting amino acids 485-592 of INSR).

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human liver

Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg

Normal Tissue Figure 4 Colon

landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg

Normal Tissue Figure 5 Liver

Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg

Normal Tissue Figure 7 Testis

Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg

Normal Tissue Figure 8 Skeletal muscle

Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg

Normal Tissue Figure 9 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR

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Specifications

Host Animal 1
Human

Host Animal 2
Human

Specificity
Human INSR

Species Reactivity
Human

Type
Tandem scFv

Valency
1 + 1

Clone 1
IR 18-146

Clone 2
IR 47-46

Epitope 1
aa 191-290

Epitope 2
aa 485-592

Purity
>90%

Purification
Affinity purified

Applications
ELISA

Concentration
Lot specific

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

Long Name
Insulin Receptor

Target

Introduction
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Alternative Names
Insulin Receptor

Gene ID
3643

UniProt ID
P06213

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Related Signaling Pathways

PPAR Signaling Pathway

Related Diseases

Type I Diabetes Mellitus

Downloadable Resources

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Datasheet

Datasheet - VS-0525-YC114.pdf

MSDS

MSDS - VS-0525-YC114.pdf

COA

Certificate of Analysis Lookup

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