Recombinant Anti-INSR (AA 191-290 x AA 485-592) Biparatopic Antibody, Tandem scFv (Clone IR 18-146 x Clone IR 47-46) (CAT#: VS-0525-YC114)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human INSR

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• IR 18-146

• Clone 2
• IR 47-46

• Epitope 1
• aa 191-290

• Epitope 2
• aa 485-592

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Insulin Receptor

• Introduction
• This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

• Alternative Names
• Insulin Receptor

• Gene ID
• 3643

• UniProt ID
• P06213

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