Recombinant Anti-INSR (AA 191-290 x AA 485-592) Biparatopic Antibody, Tandem scFv (Clone IR 18-146 x Clone IR 47-46)
CAT#: VS-0525-YC114
The Recombinant Anti-INSR (AA 191-290 x AA 485-592) Biparatopic Antibody, Tandem scFv (Clone IR 18-146 x Clone IR 47-46) is a biparatopic antibody (bpAb) designed for dual epitope binding on INSR. The bpAb's tandem scFv structure comprises the IR 18-146 scFv (specific for amino acids 191-290 of INSR) N-terminally fused to the IR 47-46 scFv (targeting amino acids 485-592 of INSR).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg
Normal Tissue
Figure 8 Skeletal muscle
Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human INSR
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- IR 18-146
- Clone 2
- IR 47-46
- Epitope 1
- aa 191-290
- Epitope 2
- aa 485-592
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Insulin Receptor
Target
- Introduction
- This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
- Alternative Names
- Insulin Receptor
- Gene ID
- 3643
- UniProt ID
- P06213
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Related Signaling Pathways
PPAR Signaling Pathway
Related Diseases
Type I Diabetes Mellitus
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "INSR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-441CL | Human Anti-INSR Recombinant Antibody (TAB-441CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-246 | Mouse Anti-INSR Recombinant Antibody (clone 83-7); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| PSBZ-083 | Mouse Anti-INSR Recombinant Antibody (clone 83-14); scFv Fragment | WB, FuncS | Mouse scFv |
| HPAB-0129-YC-S(P) | Mouse Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-0129-YC-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2351LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2351LY-S(P)) | ELISA, WB | Humanized scfv |
| HPAB-2352LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2352LY-S(P)) | ELISA, WB | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-083 | Mouse Anti-INSR Recombinant Antibody (clone 83-14); Fab Fragment | WB, FuncS | Mouse Fab |
| HPAB-2351LY-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-2351LY-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-2352LY-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-2352LY-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-2353LY-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-2353LY-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-2354LY-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-2354LY-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-711LC | Human Anti-INSR Recombinant Antibody (TAB-711LC) | ELISA, FC, FuncS | Human IgG |
| TAB-711LC-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (TAB-711LC-S(P)) | ELISA, FC | Human scFv |
| TAB-712LC-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (TAB-712LC-S(P)) | ELISA, FC | Human scFv |
| TAB-711LC-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (TAB-711LC-F(E)) | ELISA, FC | Human Fab |
| TAB-712LC-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (TAB-712LC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-124 | Recombinant Mouse Anti-IR Antibody (Fab83-14) | Neut, FuncS | IgG |
| PABX-125 | Recombinant Mouse Anti-IR Antibody (Fab83-7) | WB, ELISA, FuncS | IgG |
| PABX-124-F (E) | Recombinant Mouse Anti-IR Antibody Fab Fragment (Fab83-14 ) | Neut, FuncS | Fab |
| PABX-125-F (E) | Recombinant Mouse Anti-IR Antibody Fab Fragment (Fab83-7 ) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1205 | PE-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer | FCM | |
| MHC-LC1206 | APC-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer | FCM | |
| MHC-LC1207 | BV421-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1533CQ | Mouse Anti-INSR Recombinant Antibody (NEUT-1533CQ) | Inhib, IP | Mouse IgG2a |
| NEUT-1535CQ | Mouse Anti-INSR Recombinant Antibody (clone 47-9) | FC, Block, WB | Mouse IgG1 |
| NEUT-1536CQ | Mouse Anti-INSR Recombinant Antibody (clone 18-44) | FC, ICC, IF, Block, FuncS, IP, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1534CQ | Mouse Anti-INSR Recombinant Antibody (clone 29B4) | IP, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1844 | Rabbit Anti-INSR Recombinant Antibody (clone DS1844AB) | ICC, IP, WB | Rabbit IgG |
| MOR-4630 | Rabbit Anti-INSR Recombinant Antibody (clone TH143DS) | WB | Rabbit IgG |
| MOR-4688 | Rabbit Anti-INSR Recombinant Antibody (clone TH202DS) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2351LY | Human Anti-INSR Recombinant Antibody (HPAB-2351LY) | ELISA, WB, FC, FuncS | Humanized IgG |
| HPAB-2352LY | Human Anti-INSR Recombinant Antibody (HPAB-2352LY) | ELISA, WB, FC, FuncS | Humanized IgG |
| HPAB-2353LY | Human Anti-INSR Recombinant Antibody (HPAB-2353LY) | ELISA, WB | Humanized IgG |
| HPAB-2354LY | Human Anti-INSR Recombinant Antibody (HPAB-2354LY) | ELISA, WB | Humanized IgG |
| HPAB-2355LY | Human Anti-INSR Recombinant Antibody (HPAB-2355LY) | ELISA, WB | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY155 | AbPlus™ Anti-INSR Magnetic Beads (1.B.109) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY148 | CytoStream™ Mouse Anti-INSR Recombinant Antibody (VS-0225-XY148) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY78 | Mouse Anti-INSR scFv-Fc Chimera (VS-0325-FY78) | IA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC382 | Recombinant Anti-INSR Vesicular Antibody, EV Displayed (VS-0425-YC382) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3571 | Anti-INSR Immunohistochemistry Kit | IHC | |
| VS-0525-XY3572 | Anti-Human INSR Immunohistochemistry Kit | IHC |
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