AbPlus™ Anti-INSR Magnetic Beads (1.B.109)
CAT#: VS-0424-XY155
The AbPlus Anti-INSR Magnetic Beads (1.B.109) is an innovative affinity resin which is bound with anti-INSR specific antibody (1.B.109). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of INSR protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg
Normal Tissue
Figure 8 Skeletal muscle
Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR
❮
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-INSR specific antibody (1.B.109)
- Target
- INSR
- Immunogen
- Purified human alpha subunit of INSR
- Target Species
- Human
- Antibody Clone
- 1.B.109
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- INSR; insulin receptor; HHF5; CD220; IR
- Gene ID
- 3643
- UniProt ID
- P06213
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Related Signaling Pathways
PPAR Signaling Pathway
Related Diseases
Type I Diabetes Mellitus
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "INSR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-441CL | Human Anti-INSR Recombinant Antibody (TAB-441CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-246 | Mouse Anti-INSR Recombinant Antibody (clone 83-7); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| PFBZ-083 | Mouse Anti-INSR Recombinant Antibody (clone 83-14); Fab Fragment | WB, FuncS | Mouse Fab |
| HPAB-0129-YC-F(E) | Mouse Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-0129-YC-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2351LY-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-2351LY-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-2352LY-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (HPAB-2352LY-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-083 | Mouse Anti-INSR Recombinant Antibody (clone 83-14); scFv Fragment | WB, FuncS | Mouse scFv |
| HPAB-2351LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2351LY-S(P)) | ELISA, WB | Humanized scfv |
| HPAB-2352LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2352LY-S(P)) | ELISA, WB | Humanized scfv |
| HPAB-2353LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2353LY-S(P)) | ELISA, WB | Humanized scfv |
| HPAB-2354LY-S(P) | Human Anti-INSR Recombinant Antibody; scFv Fragment (HPAB-2354LY-S(P)) | ELISA, WB | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-711LC | Human Anti-INSR Recombinant Antibody (TAB-711LC) | ELISA, FC, FuncS | Human IgG |
| TAB-711LC-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (TAB-711LC-F(E)) | ELISA, FC | Human Fab |
| TAB-712LC-F(E) | Human Anti-INSR Recombinant Antibody; Fab Fragment (TAB-712LC-F(E)) | ELISA, FC | Human Fab |
| PABX-124-S (P) | Recombinant Mouse Anti-IR Antibody scFv Fragment (Fab83-14) | Neut, FuncS | scFv |
| PABX-125-S (P) | Recombinant Mouse Anti-IR Antibody scFv Fragment (Fab83-7) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-124 | Recombinant Mouse Anti-IR Antibody (Fab83-14) | Neut, FuncS | IgG |
| PABX-125 | Recombinant Mouse Anti-IR Antibody (Fab83-7) | WB, ELISA, FuncS | IgG |
| PABX-124-F (E) | Recombinant Mouse Anti-IR Antibody Fab Fragment (Fab83-14 ) | Neut, FuncS | Fab |
| PABX-125-F (E) | Recombinant Mouse Anti-IR Antibody Fab Fragment (Fab83-7 ) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1205 | PE-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer | FCM | |
| MHC-LC1206 | APC-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer | FCM | |
| MHC-LC1207 | BV421-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1533CQ | Mouse Anti-INSR Recombinant Antibody (NEUT-1533CQ) | Inhib, IP | Mouse IgG2a |
| NEUT-1535CQ | Mouse Anti-INSR Recombinant Antibody (clone 47-9) | FC, Block, WB | Mouse IgG1 |
| NEUT-1536CQ | Mouse Anti-INSR Recombinant Antibody (clone 18-44) | FC, ICC, IF, Block, FuncS, IP, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1534CQ | Mouse Anti-INSR Recombinant Antibody (clone 29B4) | IP, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1844 | Rabbit Anti-INSR Recombinant Antibody (clone DS1844AB) | ICC, IP, WB | Rabbit IgG |
| MOR-4630 | Rabbit Anti-INSR Recombinant Antibody (clone TH143DS) | WB | Rabbit IgG |
| MOR-4688 | Rabbit Anti-INSR Recombinant Antibody (clone TH202DS) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1171CQ | Human Anti-INSR Recombinant Antibody (clone IR 18-146) | FC | Human IgG1 |
| FAMAB-1172CQ | Human Anti-INSR Recombinant Antibody (clone IR 47-46) | Block, IB, IP | Human IgG1 |
| FAMAB-1173CQ | Human Anti-INSR Recombinant Antibody (clone IR 83-22) | IB, Inhib, IP | Human IgG1 |
| FAMAB-1174CQ | Human Anti-INSR Recombinant Antibody (clone IR 25-49) | Block, IP, Stim | Human IgG1 |
| FAMAB-1175CQ | Human Anti-INSR Recombinant Antibody (clone IR 18-40) | IB, IP | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY148 | CytoStream™ Mouse Anti-INSR Recombinant Antibody (VS-0225-XY148) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY78 | Mouse Anti-INSR scFv-Fc Chimera (VS-0325-FY78) | IA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC382 | Recombinant Anti-INSR Vesicular Antibody, EV Displayed (VS-0425-YC382) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3571 | Anti-INSR Immunohistochemistry Kit | IHC | |
| VS-0525-XY3572 | Anti-Human INSR Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC114 | Recombinant Anti-INSR (AA 191-290 x AA 485-592) Biparatopic Antibody, Tandem scFv (Clone IR 18-146 x Clone IR 47-46) | ELISA | Tandem scFv |
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