Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone B12) (CAT#: FAMAB-0114JF)
Anti-integrin αIIbβ3 antibody (B12) is full length human monoclonal antibody that binds to integrin αIIbβ3. B12 can be used in the study of post-transfusion purpura (PTP) disease.
Specific Inquiry
IHC
Figure 1 Bcl-3 is expressed in aggregated human platelets activated by thrombin.
The figures are representative of multiple experiments with thrombinstimulated platelets and of six experiments examining the effects of antiintegrin antibodies. Bar, 10 mm
Pabla, R., Weyrich, A. S., Dixon, D. A., Bray, P. F., McIntyre, T. M., Prescott, S. M., & Zimmerman, G. A. (1999). Integrin-dependent control of translation: engagement of integrin αIIbβ3 regulates synthesis of proteins in activated human platelets. The Journal of cell biology, 144(1), 175-184.
WB
Figure 2 Removal of extracellular calcium prevents platelet aggregation and inhibits Bcl-3 synthesis.
Chelation of extracellular calcium abolished platelet aggregation.
Pabla, R., Weyrich, A. S., Dixon, D. A., Bray, P. F., McIntyre, T. M., Prescott, S. M., & Zimmerman, G. A. (1999). Integrin-dependent control of translation: engagement of integrin αIIbβ3 regulates synthesis of proteins in activated human platelets. The Journal of cell biology, 144(1), 175-184.
ELISA
Figure 3 Thrombin triggered release of RANTES by platelets pretreated with EGTA as well as by control platelets.
These results are representative of seven independent experiments.
Pabla, R., Weyrich, A. S., Dixon, D. A., Bray, P. F., McIntyre, T. M., Prescott, S. M., & Zimmerman, G. A. (1999). Integrin-dependent control of translation: engagement of integrin αIIbβ3 regulates synthesis of proteins in activated human platelets. The Journal of cell biology, 144(1), 175-184.
Specifications
- Host Species
- Human
- Derivation
- Human phage display scFv library
- Type
- Human IgG
- Specificity
- Human Integrin αIIbβ3
- Species Reactivity
- Human
- Clone
- B12
- Applications
- WB, ELISA, IHC
- Related Disease
- Post-transfusion purpura
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The Integrin αIIbβ3 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
- Alternative Names
- Integrin αIIbβ3; Integrin Alpha IIb Beta 3; GPIIb/IIIa; glycoprotein IIb/IIIa; ITGA2B; ITGB3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-247 | Mouse Anti-integrin αIIbβ3 Recombinant Antibody (clone 10E5) | WB, ELISA, IF, FuncS | Mouse IgG |
| FAMAB-0113JF | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone 2F2) | WB, ELISA | Human IgG |
| VS2-QX3 | Mouse Anti-Integrin αIIbβ3 Recombinant Antibody (clone PAB-1) | IF | Mouse IgG1, κ |
| VS2-QX4 | Mouse Anti-Integrin αIIbβ3 Recombinant Antibody (clone PAB-6) | IF | Mouse IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-247 | Mouse Anti-integrin αIIbβ3 Recombinant Antibody (clone 10E5); scFv Fragment | WB, ELISA, IF, FuncS | Mouse scFv |
| FAMAB-0113JF-S(P) | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone 2F2); scFv Fragment | IF, ELISA, FuncS | Human scFv |
| FAMAB-0114JF-S(P) | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone B12); scFv Fragment | IF, ELISA, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-247 | Mouse Anti-integrin αIIbβ3 Recombinant Antibody (clone 10E5); Fab Fragment | WB, ELISA, IF, FuncS | Mouse Fab |
| FAMAB-0113JF-F(E) | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone 2F2); Fab Fragment | IF, ELISA, FuncS | Human Fab |
| FAMAB-0114JF-F(E) | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone B12); Fab Fragment | IF, ELISA, FuncS | Human Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-746LC | Anti-human Integrin αIIbβ3 Recombinant Antibody (Chimeric C4G1) (TAB-746LC) | ELISA, FC, Inhib | Chimeric antibody (mouse/human) |
| TAB-753LC | Anti-human Integrin αIIbβ3 Recombinant Antibody (c3C7) (TAB-753LC) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-746LC-S(P) | Anti-human Integrin αIIbβ3 scFv Fragment (Chimeric C4G1) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-753LC-S(P) | Anti-human Integrin αIIbβ3 scFv Fragment (c3C7) | ELISA | Chimeric antibody (mouse/human) |
| TAB-753LC-F(E) | Anti-human Integrin αIIbβ3 Fab Fragment (c3C7) | ELISA | Chimeric antibody (mouse/human) |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-747LC | Anti-human Integrin αIIbβ3 Recombinant Antibody (Humanized C4G1 ) (TAB-747LC) | ELISA, FC | Humanized antibody |
| TAB-747LC-S(P) | Anti-human Integrin αIIbβ3 scFv Fragment (Humanized C4G1 ) | ELISA, FC | Humanized antibody |
| TAB-751LC-S(P) | Human Anti-Integrin αIIbβ3 Recombinant Antibody; scFv Fragment (TAB-751LC-S(P)) | ELISA, FC | Humanized scFv |
| TAB-752LC-S(P) | Human Anti-Integrin αIIbβ3 Recombinant Antibody; scFv Fragment (TAB-752LC-S(P)) | ELISA, FC | Humanized scFv |
| TAB-751LC-F(E) | Human Anti-Integrin αIIbβ3 Recombinant Antibody; Fab Fragment (TAB-751LC-F(E)) | ELISA, FC | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-748LC | Human Anti-Integrin αIIbβ3 Recombinant Antibody (TAB-748LC) | FC, FuncS | Human IgG |
| TAB-749LC | Human Anti-Integrin αIIbβ3 Recombinant Antibody (TAB-749LC) | ELISA, FC | Human IgG |
| TAB-748LC-F(E) | Human Anti-Integrin αIIbβ3 Recombinant Antibody; Fab Fragment (TAB-748LC-F(E)) | ELISA, FC | Human Fab |
| TAB-749LC-F(E) | Human Anti-Integrin αIIbβ3 Recombinant Antibody; Fab Fragment (TAB-749LC-F(E)) | ELISA, FC | Human Fab |
| TAB-754LC-F(E) | Anti-human Integrin αIIbβ3 Fab Fragment (RAD87) | ELISA, FC | Human antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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