Anti-IQGAP1 (clone W24V108) Recombinant Antibody Coupled Liposome (VS-1024-FY110) (CAT#: VS-1024-FY110)

• Potential Clinical Applications
• Glioma

• Clone
• W24V108

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that was designed with specificity to target human IQGAP1. The antibody is engineered to recognize and bind exclusively to the IQGAP1 protein, which is involved in various cellular processes, including cell signaling and cytoskeletal dynamics. Its unique properties make it a valuable tool for research and diagnostics in applications related to cell biology and cancer research, enabling scientists to study the role of IQGAP1 in health and disease.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• IQGAP1

• Introduction
• This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.

• Alternative Names
• IQ Motif Containing GTPase Activating Protein 1

• Full Name
• IQ Motif Containing GTPase Activating Protein 1

• Gene ID
• 8826

• UniProt ID
• P46940

• Cellular Localization
• Cell membrane, Nucleus, Cytoplasm

• Post Translation Modifications
• Ubiquitination at Lys88, Lys348, Lys811, Lys1088, Lys1144, Lys1155, Lys1165, Lys1230, Lys1477, and Lys1528 (NX_P46940 [NX_P46940-1])
  Modification sites at PhosphoSitePlus (P46940)
  Glycosylation from GlyGen (P46940) 2 sites, 2 O-linked glycans (2 sites)

• Protein Refseq
• XP_047289160.1

• Function
• Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton.
  Binds to activated CDC42 but does not stimulate its GTPase activity.
  It associates with calmodulin.
  Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane.

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