Anti-IQGAP1 (clone W24V108) Recombinant Antibody Coupled Liposome (VS-1024-FY110)
CAT#: VS-1024-FY110
The use of liposomes bound to anti-IQGAP1 antibodies demonstrates significant promise in the field of glioma research, particularly due to the critical role that IQGAP1 plays in the progression of glioblastoma multiforme. Studies have shown that targeting IQGAP1 with specific antibodies can alter tumor growth dynamics, potentially leading to improved therapeutic outcomes for patients suffering from this aggressive form of brain cancer. Moreover, the diagnostic capabilities of these liposome-conjugated antibodies offer new avenues for early detection and monitoring of glioma, which could be pivotal in enhancing patient prognosis and treatment strategies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/671_E1_1_selected.jpg
Normal Tissue
Figure 2 Endometrium 1
High expression in endometrium 1
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14055/33083_B_6_3_val_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_A_5_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_A_9_8.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_B_9_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_A_7_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13302/32877_A_9_4.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000140575-IQGAP1
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V108
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was designed with specificity to target human IQGAP1. The antibody is engineered to recognize and bind exclusively to the IQGAP1 protein, which is involved in various cellular processes, including cell signaling and cytoskeletal dynamics. Its unique properties make it a valuable tool for research and diagnostics in applications related to cell biology and cancer research, enabling scientists to study the role of IQGAP1 in health and disease.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IQGAP1
- Introduction
- This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
- Alternative Names
- IQ Motif Containing GTPase Activating Protein 1
- Full Name
- IQ Motif Containing GTPase Activating Protein 1
- Gene ID
- 8826
- UniProt ID
- P46940
- Cellular Localization
- Cell membrane, Nucleus, Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys88, Lys348, Lys811, Lys1088, Lys1144, Lys1155, Lys1165, Lys1230, Lys1477, and Lys1528 (NX_P46940 [NX_P46940-1])
Modification sites at PhosphoSitePlus (P46940)
Glycosylation from GlyGen (P46940) 2 sites, 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_047289160.1
- Function
- Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton.
Binds to activated CDC42 but does not stimulate its GTPase activity.
It associates with calmodulin.
Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane.
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Downloadable Resources
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Datasheet
MSDS
COA
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| MOB-0988CT | Recombinant Mouse anti-Human IQGAP1 Monoclonal antibody (EML945) | ICC, IF, IHC-P, WB |
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| MOR-1849 | Hi-Affi™ Recombinant Rabbit Anti-IQGAP1 Monoclonal Antibody (DS1849AB) | ICC, IHC-P, WB | IgG |
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| CAT | Product Name | Application | Type |
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| VS3-WK489 | Rabbit Anti-IQGAP1 Recombinant Antibody (clone JG38-74) | WB, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| VS3-XY3395 | Rabbit Anti-IQGAP1 Recombinant Antibody (clone R01-9S9) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY283 | Mouse Anti-NHP IQGAP1 Recombinant Antibody (clone AF1) | WB, IF | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3577 | Anti-Human IQGAP1 Immunohistochemistry Kit | IHC |
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