Human Anti-ITGA3 Recombinant Antibody (VS-0524-YC40)
CAT#: VS-0524-YC40
The antibody targets human integrin subunit alpha 3. It is capable of specifically recognizing a cancer cell and exhibiting a damaging effect by the ADCC activity. The antibody also recognized a VLA complex.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18594/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18594/204_G7_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18594/203_G7_1_blue_red_green.jpg
Normal Tissue
Figure 4 Lung
Alveolar cells type I
Staining: High
Intensity: Strong
Quantity: 75%-25%
Alveolar cells type II
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_2_4.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HBEC3-KT, hTERT-RPE1, RPTEC TERT1, U-87 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005884-ITGA3
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Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human integrin subunit alpha 3
- Species Reactivity
- Human
- Applications
- FC, ADCC
- Related Disease
- Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome and Nephrotic Syndrome.
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservative
- Storage
- Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Integrin Subunit Alpha 3
- Gene ID
- 3675
- UniProt ID
- P26006
- Long Name
- Integrin Subunit Alpha 3
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Cell membrane; invadopodium membrane; filopodium membrane
- Post Translation Modifications
- Isoform 1, but not isoform 2, is phosphorylated on serine residues.
Glycosylation at Asn86, Asn107, Asn265, Asn500, Asn511, Asn573, Asn605, Asn656, Asn697, Asn841, Asn857, Asn926, Asn935, and Asn969.
- Protein Refseq
- XP_005257365.1; XP_047291878.1; XP_054171933.1; XP_054171934.1; NP_002195.1
- Function
- Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2262MZ | Recombinant Mouse Anti-Human ITGA3 Antibody (clone 28D7), FITC-Conjugated | FC | Mouse antibody |
| ZG-0963F | Mouse Anti-ITGA3 Recombinant Antibody (clone 158A3) | ICC, IHC-Fr, WB | Mouse IgG2a |
| ZG-0976F | Mouse Anti-ITGA3 Recombinant Antibody (clone 29A3) | ICC, IHC-Fr, WB | Mouse IgG1 |
| ZG-0994F | Mouse Anti-ITGA3 Recombinant Antibody (clone 54B3) | ICC, IHC-Fr, WB | Mouse IgG1 |
| ZG-1072F | Mouse Anti-ITGA3 Recombinant Antibody (clone PB36) | ICC, IHC-Fr, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0294MZ | Chicken Anti-ITGA3 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-CN-S(P) | Human Anti-ITGA3 Recombinant Antibody; scFv Fragment (HPAB-0016-CN-S(P)) | ELISA | Human scFv |
| HPAB-0017-CN-S(P) | Human Anti-ITGA3 Recombinant Antibody; scFv Fragment (HPAB-0017-CN-S(P)) | ELISA | Human scFv |
| HPAB-0018-CN-S(P) | Mouse Anti-ITGA3 Recombinant Antibody (clone ITGa3-VM2); scFv Fragment | IF, ELISA, IP | Mouse scFv |
| HPAB-1659LY-S(P) | Mouse Anti-ITGA3 Recombinant Antibody; scFv Fragment (HPAB-1659LY-S(P)) | ELISA | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-CN-F(E) | Human Anti-ITGA3 Recombinant Antibody; Fab Fragment (HPAB-0016-CN-F(E)) | ELISA | Human Fab |
| HPAB-0017-CN-F(E) | Human Anti-ITGA3 Recombinant Antibody; Fab Fragment (HPAB-0017-CN-F(E)) | ELISA | Human Fab |
| HPAB-0018-CN-F(E) | Mouse Anti-ITGA3 Recombinant Antibody (clone ITGa3-VM2); Fab Fragment | IF, ELISA, IP | Mouse Fab |
| HPAB-1659LY-F(E) | Mouse Anti-ITGA3 Recombinant Antibody; Fab Fragment (HPAB-1659LY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1461-FY | Recombinant Anti-ITGA3 Single Domain Antibody (HPAB-1461-FY) | ELISA, FC | Llama VHH |
| HPAB-0778-YJ-VHH | Camelid Anti-ITGA3 Recombinant Single Domain Antibody (HPAB-0778-YJ-VHH) | ELISA, Inhib | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1154 | Anti-ITGA3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3622 | Anti-Human ITGA3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC678 | Recombinant Anti-ITGA3 Vesicular Antibody, EV Displayed (VS-0425-YC678) | ELISA, FC, Cell-uptake |
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