Rabbit Anti-ITGAX Polyclonal Antibody (VS13-YC602) (CAT#: VS13-YC602)
The Rabbit Anti-ITGAX Polyclonal Antibody is specific for human and rat ITGAX. ITGAX encodes the integrin alpha X chain, forming leukocyte-specific integrins with the beta 2 chain, referred to as the iC3b receptor 4 (CR4). This complex aids in neutrophil and monocyte adherence to endothelium cells and phagocytosis of complement-coated particles, with two transcript variants encoding different isoforms. The anti-ITGAX antibody can be used for ELISA (1/5000-1/10000).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 High expression in spleen
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4723/14046_B_7_4_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4723/14046_B_7_4_selected.jpg
Figure 2 Low expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4723/14046_B_9_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4723/14046_B_9_5_val_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_B_7_5.jpg
(Glial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_B_7_5.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_A_7_8.jpg
Figure 5 Spleen
(Cells in red pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_B_8_4.jpg
(Cells in red pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_B_8_4.jpg
Figure 6 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140678-ITGAX
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140678-ITGAX
Specifications
- Immunogen
- Recombinant human Integrin alpha X (aa 501-600) conjugated with KLH.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat ITGAX
- Species Reactivity
- Human, Rat, Mouse (Predicted), Dog (Predicted)
- Applications
- ELISA
- Conjugate
- NONE
- Related Disease
- Hairy Cell Leukemia; Sporotrichosis
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01× TBS (pH 7.4) containing 50% Glycerol and 1% BSA.
- Preservative
- 0.03% Proclin 300
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- ELISA: 1/5000-1/10000
Target
- Alternative Names
- Integrin Subunit Alpha X
- Gene ID
- 3687
- UniProt ID
- P20702
- Long Name
- Integrin Subunit Alpha X
- Cellular Localization
- Membrane
- Protein Refseq
- XP_011544154.1; XP_011544156.1
- Function
- Integrin alpha-X/beta-2 is a receptor for fibrinogen.
It recognizes the sequence G-P-R in fibrinogen.
It mediates cell-cell interaction during inflammatory responses.
It is especially important in monocyte adhesion and chemotaxis.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ITGAX"
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1580CL | Hamster Anti-ITGAX Recombinant Antibody (TAB-1580CL) | FC | Hamster IgG1, κ |
| TAB-1580CL-S(P) | Hamster Anti-ITGAX Recombinant Antibody; scFv Fragment (TAB-1580CL-S(P)) | FC | Hamster scFv |
| TAB-1580CL-F(E) | Hamster Anti-ITGAX Recombinant Antibody; Fab Fragment (TAB-1580CL-F(E)) | FC | Hamster Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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