Rabbit Anti-ITGAX Recombinant Antibody (clone R06-5A7) (CAT#: VS3-XY3401)
This antibody is a recombinant rabbit antibody targeting the ITGAX (Integrin subunit alpha X), which mediates cell-cell interaction during inflammatory responses. It specifically reacts with human ITGAX. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation and Immunofluorescence is 1/500-1/1000, 1/50-1/100, 1/20 and 1/50-1/200, respectively.
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Normal Tissue
RNA Expression
Figure 1 High expression in spleen
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4723/14046_B_7_4_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4723/14046_B_7_4_selected.jpg
Figure 2 Low expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4723/14046_B_9_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4723/14046_B_9_5_val_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_B_7_5.jpg
(Glial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_B_7_5.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_A_7_8.jpg
Figure 5 Spleen
(Cells in red pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_B_8_4.jpg
(Cells in red pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4458/14042_B_8_4.jpg
Figure 6 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140678-ITGAX
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140678-ITGAX
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human ITGAX
- Species Reactivity
- Human
- Clone
- R06-5A7
- Applications
- WB, IHC-P, ICC, IF, IP
- Related Disease
- Hairy Cell Leukemia; Sporotrichosis
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- CD11C; SLEB6
- Gene ID
- 3687
- UniProt ID
- P20702
- Long Name
- Integrin subunit alpha X
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn61, Asn89, Asn392, Asn697, Asn735, Asn899, Asn904, Asn939, and Asn1050 (NX_P20702 [NX_P20702-1])
Modification sites at PhosphoSitePlus (P20702)
Glycosylation from GlyConnect ITAX_HUMAN (1413)
Glycosylation from GlyGen (P20702) 8 sites, 2 N-linked glycans (3 sites)
- Protein Refseq
- XP_011544154.1; XP_011544156.1
- Function
- Integrin alpha-X/beta-2 is a receptor for fibrinogen.
It recognizes the sequence G-P-R in fibrinogen.
It mediates cell-cell interaction during inflammatory responses.
It is especially important in monocyte adhesion and chemotaxis.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1580CL | Hamster Anti-ITGAX Recombinant Antibody (TAB-1580CL) | FC | Hamster IgG1, κ |
| TAB-1580CL-S(P) | Hamster Anti-ITGAX Recombinant Antibody; scFv Fragment (TAB-1580CL-S(P)) | FC | Hamster scFv |
| TAB-1580CL-F(E) | Hamster Anti-ITGAX Recombinant Antibody; Fab Fragment (TAB-1580CL-F(E)) | FC | Hamster Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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