Rat Anti-ITGB1 Recombinant Antibody (clone MAb AIIB2) (CAT#: HPAB-0254CQ)

This product is a recombinant Rat antibody that can bind to ITGB1 with high affinity.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Block

Figure 1 D283 medulloblastoma cells adhered to type I collagen matrix via the ITGB1 in vitro.

Figure 1 D283 medulloblastoma cells adhered to type I collagen matrix via the ITGB1 in vitro.

The inhibitory monoclonal antibody, AIIB2, blocked this interaction, whereas the activating monoclonal antibody, P4G11, did not. The data were plotted from a representative experiment with quadruplicates, and * indicates a P value of 0.0017

Liang, Y., Diehn, M., Bollen, A. W., Israel, M. A., & Gupta, N. (2008). Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment. Journal of neuro-oncology, 86(2), 133-141.

IF

Figure 2 The integrin β1–activating mAb P4G11 abrogates the invasive phenotype in CRC cells in 3D.

Figure 2 The integrin β1–activating mAb P4G11 abrogates the invasive phenotype in CRC cells in 3D.

SC cells were plated in 3D type 1 collagen as single cells in the presence or absence of integrin β1 mAbs (10 µg/ml) as indicated. The medium was replaced every 2–3 d until day 15, when colonies were fixed and stained with phalloidin (red) and DAPI (blue). Scale bar, 100 µm.

Starchenko, A., Graves-Deal, R., Yang, Y. P., Li, C., Zent, R., Singh, B., & Coffey, R. J. (2017). Clustering of integrin α5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells. Molecular biology of the cell, 28(10), 1288-1300.


Specifications

  • Host Species
  • Rat
  • Derivation
  • Rat
  • Type
  • Rat IgG1, κ
  • Species Reactivity
  • Human, Cattle, Porcine, Sheep, Horse, Canine, Monkey
  • Clone
  • MAb AIIB2
  • Applications
  • ELISA, FC, WB, ICC, Block, IP, IF, IHC

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Immunofluorescence and Blocking. Please see the Published Data for further information.

Target

  • Alternative Names
  • Integrin Subunit Beta 1

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone MAb AIIB2"

See other products for "ITGB1"

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0277MZ Chicken Anti-Integrin β1 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1585CQ Recombinant Mouse Anti-ITGB1 Antibody (CBL252) FC, ELISA, WB, IP, FuncS, Inhib IgG1
NEUT-1587CQ Recombinant Mouse Anti-ITGB1 Antibody (P5D2) BL, FC, IP, CyTOF, ICC IgG1
NEUT-1588CQ Recombinant Armenian Hamster Anti-Itgb1 Antibody (HMβ1-1) FC, IP, BL, IHC IgG

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1586CQ Recombinant Mouse Anti-ITGB1 Antibody (P4C10) WB, Neut, ELISA, FC, ICC/IF, IHC-Fr, IP IgG1
NEUT-1589CQ Recombinant Armenian hamster Anti-Itgb1 Antibody (HMb1-1) FC, FuncS, Neut IgG

Rabbit Monoclonal Antibody

Neuroscience Antibody

CAT Product Name Application Type
NS-047CN Human Anti-ITGB1 Recombinant Antibody ELISA, WB, IHC Human IgG

scFv Fragment Antibody

CAT Product Name Application Type
NS-047CN-S(P) Human Anti-ITGB1 Recombinant Antibody; scFv Fragment ELISA, WB, IHC Human scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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