Mouse Anti-ITGB2 Monoclonal Antibody (VS7-0425-WR160)
CAT#: VS7-0425-WR160
This product is a mouse IgG antibody that binds to human ITGB2. The antibody can be used for IF, ICC, and ELISA assays. It cross reacts with mouse.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line BJ
Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
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Specifications
- Immunogen
- Recombinant human ITGB2 fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ITGB2
- Species Reactivity
- Human, Mouse
- Molecule Class
- Integrin
- Applications
- IF, ICC, ELISA
- Conjugate
- Unconjugated
- Related Disease
- Leukocyte adhesion deficiency (LAD).
Increased susceptibility to infections.
Involved in long term pulmonary complications after COVID-19 infection.
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- 1 mg/mL
- Preservative
- 0.03% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunofluorescence: 1:200 - 1:1000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
- Gene ID
- 3689
- UniProt ID
- P05107
- Long Name
- Integrin Subunit Beta 2
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305).
Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).
- Protein Refseq
- NP_000202.3
- Function
- Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980).
Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| NABG-099 | Recombinant Anti-Human ITGB2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1581CL | Anti-Human ITGB2 Recombinant Antibody (23F2G) | Inhib | |
| TAB-1581CL-S(P) | Anti-Human ITGB2 Recombinant Antibody scFv Fragment (23F2G) | Inhib | |
| TAB-1581CL-F(E) | Anti-Human ITGB2 Recombinant Antibody Fab Fragment (23F2G) | Inhib |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0298MZ | Chicken Anti-ITGB2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203CQ-S(P) | Mouse Anti-ITGB2 Recombinant Antibody (clone 60.3); scFv Fragment | ELISA, WB, Block | Mouse scFv |
| HPAB-1207WJ-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone pxCD18-7T3); scFv Fragment | ELISA | Human scFv |
| HPAB-1292WJ-S(P) | Rat Anti-ITGB2 Recombinant Antibody (clone YFC51.1); scFv Fragment | ELISA, FC | Rat scFv |
| HPAB-1293WJ-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone LDP-01); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-1874-FY-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone NA-8); scFv Fragment | Block | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0283-CN | Recombinant Rabbit Anti-ITGB2 Monoclonal Antibody (JM71-31) | WB, IP | Rabbit IgG |
| FN-006CQ | Recombinant Mouse Anti-ITGB2 Antibody (IB4) | FC, Block | Mouse IgG2a |
| HPAB-1874-FY | Human Anti-ITGB2 Recombinant Antibody (clone NA-8) | Block | Human IgG1 |
| VS3-WK1449 | Mouse Anti-ITGB2 Recombinant Antibody (clone 118) | FC, IF | Mouse IgG1 |
| VS3-WK1996 | Rabbit Anti-ITGB2 (pS745) Recombinant Antibody (clone R01-4B6) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-044 | Afuco™ Anti-ITGB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-044) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY153 | CytoStream™ Mouse Anti-ITGB2 Recombinant Antibody (clone WT.3) | FC, Block, IHC, IP | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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