Mouse Anti-ITGB2 Recombinant Antibody (clone TS1/18.1.2) (CAT#: VS3-CJ399)
This product is a mouse antibody that recognizes ITGB2.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg

(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg

(Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
Specifications
- Immunogen
- Native purified human CD18
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human ITGB2
- Species Reactivity
- Human
- Clone
- TS1/18.1.2
- Applications
- IF, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunofluorescence, Flow Cytometry.
Target
- Alternative Names
- LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
- Gene ID
- 3689
- UniProt ID
- P05107
- Sequence Similarities
- Belongs to the integrin beta chain family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305).
Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).
- Protein Refseq
- NP_000202.3; NP_001120963.2; NP_001290167.1
- Function
- Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980).
Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ITGB2"
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CAT | Product Name | Application | Type |
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DrMAB-980 | Recombinant Mouse Anti-Human ITGB2 Antibody F(ab')2 Fragment, clone IB4 | FC, Inhib | F(ab')2 |
FAMAB-0203CQ-F(E) | Mouse Anti-ITGB2 Recombinant Antibody (clone 60.3); Fab Fragment | ELISA, WB, Block | Mouse Fab |
HPAB-1292WJ-F(E) | Rat Anti-ITGB2 Recombinant Antibody (clone YFC51.1); Fab Fragment | ELISA, FC | Rat Fab |
HPAB-1293WJ-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone LDP-01); Fab Fragment | ELISA, FC | Humanized Fab |
HPAB-1874-FY-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone NA-8); Fab Fragment | Block | Humanized Fab |
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