Anti-ITGB3 (clone SZ-21) Recombinant Antibody Coupled Liposome (VS-1024-FY187)
CAT#: VS-1024-FY187
The anti-ITGB3 antibody conjugated liposomes are designed to selectively target melanoma cells expressing integrin β3 (ITGB3). This strategy enhances the delivery of chemotherapeutic agents directly to cancer cells, promoting localized treatment effects. Preclinical studies indicate that this approach can improve treatment response and reduce side effects. This targeted delivery mechanism holds potential for overcoming resistance to conventional therapies.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/281_B9_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/ihc_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27852/64673_B_4_4.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (EFO-21, HEL, RPTEC TERT1, U-87 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000259207-ITGB3
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- SZ-21
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically engineered to target the integrin beta-3 subunit (ITGB3). Integrin beta-3 is a critical protein that plays a significant role in cell adhesion, signaling, and the progression of various physiological and pathological processes, including wound healing, inflammation, and tumor metastasis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ITGB3
- Introduction
- The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
- Alternative Names
- Integrin Subunit Beta 3
- Full Name
- Integrin Subunit Beta 3
- Gene ID
- 3690
- UniProt ID
- P05106
- Cellular Localization
- Cell junction, Cell membrane, Cell projection, Membrane
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Datasheet
MSDS
COA
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See other products for "Clone SZ-21"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-785-sdAb | Recombinant Anti-human ITGB3 VHH Single Domain Antibody | FA, FC, ICC, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
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| MOB-1128z | Mouse Anti-ITGB3 Recombinant Antibody (clone 19C5) | WB, FC, FuncS | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-109-F(E) | Anti-Human Integrin lpha 2b beta 3 Recombinant Antibody Fab Fragment (Tadocizumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Fab - G1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-251 | Mouse Anti-ITGB3 Recombinant Antibody (clone 314.1) | WB, ELISA, IF, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-251 | Mouse Anti-ITGB3 Recombinant Antibody (clone 314.1); scFv Fragment | WB, ELISA, IF, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-251 | Mouse Anti-ITGB3 Recombinant Antibody (clone 314.1); Fab Fragment | WB, ELISA, IF, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-083 | Mouse Anti-ITGB3 Recombinant Antibody (clone OPG2) | Block | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-083 | Mouse Anti-ITGB3 Recombinant Antibody (clone OPG2); Fab Fragment | Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-083 | Mouse Anti-ITGB3 Recombinant Antibody (clone OPG2); scFv Fragment | Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0577CL | Human Anti-ITGB3 Recombinant Antibody (TAB-0577CL) | WB, IF, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0577CL-S(P) | Human Anti-ITGB3 Recombinant Antibody; scFv Fragment (TAB-0577CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0577CL-F(E) | Human Anti-ITGB3 Recombinant Antibody; Fab Fragment (TAB-0577CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0289MZ | Recombinant Mouse Anti-Human integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Antibody (clone Z3/52) | IHC | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0299MZ | Chicken Anti-ITGB3 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1370 | PE-DRB3*01:01/Human ITGB3 (AWRSDEALPLGS) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1371 | APC-DRB3*01:01/Human ITGB3 (AWRSDEALPLGS) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1372 | BV421-DRB3*01:01/Human ITGB3 (AWRSDEALPLGS) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1598CQ | Recombinant Mouse Anti-ITGB3 Antibody (25E11) | FC, IF, Inhib | IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1599CQ | Recombinant Armenian Hamster Anti-Itgb3 Antibody (2C9.G2(HMß3-1)) | FC, BL, Activ, IHC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1600CQ | Recombinant Armenian hamster Anti-Itgb3 Antibody (2C9.G3) | FC, FuncS, Neut, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1601CQ | Recombinant Mouse Anti-ITGB3 Antibody (PM6/13) | WB, Neut, ELISA, FC, ICC, IF, IHC, IHC-Fr, IHC-P, IP, ICC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1885 | Hi-Affi™ Recombinant Rabbit Anti-ITGB3 Monoclonal Antibody (DS1885AB) | ICC, IF, IHC-P, WB, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1009LC | Recombinant Mouse Anti-ITGB3 Antibody (1E6) | FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1010LC | Recombinant Mouse Anti-ITGB3 Antibody (7E3) | FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0854-CN | Recombinant Rabbit Anti-ITGB3 Monoclonal Antibody (CBACN-315) | WB, IHC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-YJ-S(P) | Mouse Anti-ITGB3 Recombinant Antibody (clone SZ-21); scFv Fragment | WB, ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-YJ-F(E) | Mouse Anti-ITGB3 Recombinant Antibody (clone SZ-21); Fab Fragment | WB, ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC54 | Mouse Anti-ITGB3 Recombinant Antibody (VS-0924-YC54) - Cancer Stem Cell Marker | IHC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC55 | Rabbit Anti-ITGB3 Antibody (VS-0924-YC55) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY105 | Mouse Anti-NHP ITGB3 Recombinant Antibody (clone VIPL2) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1157 | Anti-ITGB3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC671 | Recombinant Anti-ITGB3 Vesicular Antibody, EV Displayed (VS-0425-YC671) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3660 | Anti-Mouse ITGB3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3659 | Anti-Human ITGB3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3661 | Anti-Rat ITGB3 Immunohistochemistry Kit | IHC |
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