Rabbit Anti-JUP Recombinant Antibody (clone R01-3P1)
CAT#: VS3-XY3403
This is a recombinant rabbit antibody that recognizes human JUP (Junction plakoglobin), which acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. It is capable of recognizing human, mouse, rat and dog JUP. It has been used in a variety of applications, such as Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to cell junctions & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32047/if_selected.jpg
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse, Rat and Dog JUP
- Species Reactivity
- Human, Mouse, Rat, Dog
- Clone
- R01-3P1
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Naxos Disease; Arrhythmogenic Right Ventricular Dysplasia, Familial, 12
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- PG; DP3; PDGB; PKGB; CTNNG; DPIII
- Gene ID
- 3728
- UniProt ID
- P14923
- Long Name
- Junction plakoglobin
- Cellular Localization
- Cell junction, Desmosome, Cytoplasm, Cytoskeleton
- Post Translation Modifications
- May be phosphorylated by FER. (P14923-PLAK_HUMAN)
Glycosylation at Thr14, Asn195, Asn211, Asn321, and Asn378 (NX_P14923 [NX_P14923-1])
Modification sites at PhosphoSitePlus (P14923)
Glycosylation from GlyConnect PLAK_HUMAN (1950)
Glycosylation from GlyGen (P14923) 6 sites, 10 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_006721938.1
- Function
- Common junctional plaque protein.
The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue.
The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells.
Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "JUP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2482z | Mouse Anti-JUP Recombinant Antibody (clone 36A6) | WB, ELISA, ICC, IF, IHC | Mouse IgG1 |
| ZG-0366F | Mouse Anti-JUP Recombinant Antibody (ZG-0366F) | WB, IHC, IF, ELISA | Mouse IgG |
| VS3-WK405 | Rabbit Anti-JUP Recombinant Antibody (clone JF0973) | WB, ICC, IF, IHC, FC | Rabbit IgG |
| VS3-FY788 | Recombinant Rabbit Anti-JUP Antibody (clone R05-0C2) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| VS7-0425-WR173 | Mouse Anti-JUP Monoclonal Antibody (clone 4C12) | WB, IHC, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1170 | Anti-JUP Immunohistochemistry Kit | IHC | |
| VS-0525-XY3708 | Anti-Mouse JUP Immunohistochemistry Kit | IHC | |
| VS-0525-XY3707 | Anti-Human JUP Immunohistochemistry Kit | IHC | |
| VS-0525-XY3709 | Anti-Rat JUP Immunohistochemistry Kit | IHC |
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