Mouse Anti-KDM5A Recombinant Antibody (VS3-CJ50)
CAT#: VS3-CJ50
This product is a mouse antibody that recognizes KDM5A.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6201/43_F7_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000073614-KDM5A
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Specifications
- Immunogen
- Recombinant fragment of human KDM5A (C-terminus)
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human KDM5A
- Species Reactivity
- Human
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- 1 mg/mL (lot specific)
- Buffer
- 50% Glycerol, 1% BSA, PBS, pH7.4.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in ELISA (1:5000-1:20000), Western Blot (1:100-1:2000).
Target
- Alternative Names
- RBBP-2; RBBP2; RBP2
- Gene ID
- 5927
- UniProt ID
- P29375
- Sequence Similarities
- Belongs to the JARID1 histone demethylase family.
- Cellular Localization
- Nucleus
- Protein Refseq
- NP_001036068.1
- Function
- Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511).
May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464).
May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "KDM5A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1432MZ | Recombinant Mouse Anti-Human KDM5A Antibody (clone 29F9) | WB | Mouse antibody |
| MRO-0896-CN | Recombinant Rabbit Anti-KDM5A Monoclonal Antibody (JB36-60) | WB, IF, FC | Rabbit IgG |
| VS3-WK289 | Rabbit Anti-KDM5A Recombinant Antibody (clone JB36-60) | WB, ELISA | Rabbit IgG |
| VS3-XY3406 | Rabbit Anti-KDM5A Recombinant Antibody (clone R02-3F8) | WB, ICC, IF, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1925 | Hi-Affi™ Recombinant Rabbit Anti-KDM5A Monoclonal Antibody (DS1925AB) | FC, WB | IgG |
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