Afuco™ Anti-KDR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-079)

Name: Afuco™ Anti-KDR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-079)
SKU: AFC-TAB-079
Rating: 5 (1 reviews)

CAT#: AFC-TAB-079

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to VEGF Receptor 2. It is a fully human monoclonal antibody (IgG1) for the treatment of solid tumors. It is directed against the vascular endothelial growth factor receptor 2 (VEGFR2). By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2. VEGFR2 is known to mediate the majority of the downstream effects of VEGF in angiogenesis.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg

Normal Tissue Figure 2 Placenta

High expression

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Antibody Isotype
IgG1, κ

Species Reactivity
Human

Applications
IP, IF, FuncS, FC, Neut, ELISA

Conjugate
Unconjugated

Trade name
Cyramza

Generic Name
Ramucirumab

Related Disease
Non-small cell lung cancers (NSCLC)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2; soluble VEGFR2; fetal liver kinase 1

Gene ID
3791

UniProt ID
P35968

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Biosimilar Overview

Please refer to Ramucirumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ramucirumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-079.pdf

MSDS

MSDS - AFC-TAB-079.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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Ramucirumab is an antineoplastic agent and direct VEGFR2 antagonist that blocks the binding of natural VEGF ligands, which solid tumors secrete to promote angiogenesis and enhance tumor blood supply. The DrugMonitor™ Anti-Ramucirumab Antibody (VS-1224-YC978) is an anti-drug antibody (ADA) against Ramucirumab. This drug-based antibody is raised in mice immunized with the Ramucirumab. The anti-Ramucirumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Ramucirumab in samples.

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