Anti-Kel Antibody Prodrug, Protease Activated (MIMA-8)
CAT#: VS-1025-YC125
The Anti-Kel Antibody Prodrug, Protease Activated (MIMA-8) is an antibody prodrug comprised of a recombinant human antibody targeting human Kell protein, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to Kel protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to Kel effectively. The Kell protein is a complex protein found on the surface of red blood cells. While not directly oncogenic, its gene is occasionally involved in chromosomal translocations that result in the fusion of the KEL gene with a tyrosine kinase gene. This fusion creates a constitutively active oncogenic kinase that can drive a rare subset of hematological malignancies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64442/1848_C11_12_cr5abb8a20c9b63_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HEL, K-562)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197993-KEL
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human Kell protein
- Target
- Kel
- Species Reactivity
- Human
- Isotype
- IgG1
- Clone
- MIMA-8
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.
- Alternative Names
- Kell Blood Group, Metallo-Endopeptidase; Truncated Kell Blood Group Glycoprotein; Kell Blood Group, Metalloendopeptidase; Kell Blood Group Glycoprotein; Kell Blood Group Antigen; Kell Glycoprotein;
- Gene ID
- 23925
- UniProt ID
- Q9EQF2
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Datasheet
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COA
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See other products for "Clone MIMA-8"
- CAT
- Product Name
See other products for "KEL"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3054z | Mouse Anti-KEL Recombinant Antibody (clone 24B1) | ELISA, IHC | Mouse IgG1 |
| MOB-0257CT | Recombinant Mouse anti-Human KEL Monoclonal antibody (NN0546-23Y4) | WB | |
| FAMAB-1373CQ | Human Anti-Kel Recombinant Antibody (clone MIMA-8) | FC | Human IgG1 |
| VS2-QX42 | Mouse Anti-KEL Recombinant Antibody (clone BRIC 18) | Haemagglutination | Mouse IgG2a, κ |
| VS2-QX43 | Mouse Anti-KEL Recombinant Antibody (clone BRIC 68) | Haemagglutination | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY166 | AbPlus™ Anti-KEL Magnetic Beads (BRIC 203) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC701 | Recombinant Anti-Kel Vesicular Antibody, EV Displayed (VS-0425-YC701) | ELISA, FC, Cell-uptake |
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