Rabbit Anti-KIF3A Recombinant Antibody (clone R03-8K9) (CAT#: VS3-XY3407)
The rabbit recombinant antibody specifically binds to human KIF3A (Kinesin family member 3A), which plays a role in centriole cohesion and subdistal appendage organization and function. It also has cross-reactivity against mouse and rat KIF3A. It has been detected using Western Blot and Immunoprecipitation.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37085/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37085/if_selected.jpg
Figure 2 IHC staining of human cerebellum
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37085/ihc_selected.jpg
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37085/ihc_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37085/72113_B_9_5.jpg
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37085/72113_B_9_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37085/72113_A_6_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37085/72113_A_6_6.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131437-KIF3A
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131437-KIF3A
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat KIF3A
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-8K9
- Applications
- WB, IP
- Related Disease
- Endocrine-Cerebroosteodysplasia; Meckel Syndrome, Type 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IP: 1/20
Target
- Alternative Names
- FLA10; KLP-20
- Gene ID
- 11127
- UniProt ID
- Q9Y496
- Long Name
- Kinesin family member 3A
- Cellular Localization
- Cytoplasm, Cytoskeleton, Cell projection, cilium
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q9Y496)
Modification sites at neXtProt (NX_Q9Y496)
Glycosylation from GlyGen (Q9Y496) 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_016864485.1; XP_006714589.1
- Function
- Microtubule-based anterograde translocator for membranous organelles.
Plus end-directed microtubule sliding activity in vitro.
Plays a role in primary cilia formation.
Plays a role in centriole cohesion and subdistal appendage organization and function.
Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole.
Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "KIF3A"
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IgG Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0962CT | Recombinant Mouse anti-Rat KIF3A Monoclonal antibody (L3.5) | BL, ICC/IF, WB | |
| MRO-1995-CN | Rabbit Anti-KIF3A Polyclonal Antibody (MRO-1995-CN) | WB, IHC, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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