Human Anti-KLKB1 Recombinant Antibody (clone STAR-0215) (CAT#: VS-0724-XY81)
The antibody STAR-0215 binds KLKB1 (Kallikrein B1) using a novel binding region. It is a novel, long-acting monoclonal antibody inhibitor of plasma kallikrein for the potential treatment of hereditary angioedema. It inhibits human plasma kallikrein to prevent bradykinin release and it potently inhibits plasma kallikrein activity in cynomolgus monkeys.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (NTERA-2, SCLC-21H, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164344-KLKB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164344-KLKB1
Specifications
- Immunogen
- Active human plasma kallikrein
- Host Species
- Human
- Derivation
- Lymphocytes
- Type
- Human IgG1
- Specificity
- KLKB1
- Species Reactivity
- Human
- Clone
- STAR-0215
- Applications
- ELISA, SPR, Neut
- Related Disease
- Prekallikrein Deficiency; Congenital Prekallikrein Deficiency
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95%, determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- SPR: The KD value of STAR-0215 agaisnt KLKB1 is 1.07 ± 0.01 nM.
Neut: The IC50 value of STAR-0215 antibody against Human plasma kallikrein is 13.0 ± 2.1 nM.
Target
- Alternative Names
- PKK; PPK; KLK3; PKKD
- Gene ID
- 3818
- UniProt ID
- P03952
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn127, Asn164, Asn254, Asn308, Asn316, Asn396, Asn453, and Asn494.
- Protein Refseq
- XP_011530232.1; XP_016863670.1; XP_016863671.1
- Function
- Participates in the surface-dependent activation of blood coagulation.
Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "KLKB1"
Select a product category from the dropdown menu below to view related products.
Please select product type
Human Antibody Products
ScFv Antibody Products
Fab Antibody Products
IgG Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-472CL | Human Anti-KLKB1 Recombinant Antibody (TAB-472CL) | Inhib, FuncS | Human IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0724-XY81. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: ELISA, FC, IP, FuncS, IF, Neut, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: WB, ELISA, FuncS
Application: FC, FRET, Internalization
Application: ELISA, FC, FuncS
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
Application: WB, IHC-Fr, IHC-P, ICC, IF
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
