Anti-KMT5A (clone W24V74) Recombinant Antibody Coupled Liposome (VS-1024-FY75)
CAT#: VS-1024-FY75
The utilization of anti-KMT5A antibody-conjugated liposomes represents a groundbreaking advancement in breast cancer therapy, offering a targeted delivery system that enhances the precision of treatment. By harnessing the unique binding capabilities of the antibodies, this method specifically directs therapeutic agents to cancer cells expressing KMT5A, thereby minimizing damage to healthy tissues. This strategic targeting not only has the potential to improve treatment efficacy but also to reduce side effects, making it a highly promising approach in the fight against breast cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64495/1273_H11_6_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000183955-KMT5A
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- W24V74
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant mouse antibody exhibits a highly specific binding affinity for the human KMT5A. This unique characteristic allows it to selectively recognize and bind to the human KMT5A, making it an invaluable tool for various research and clinical applications.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- KMT5A
- Introduction
- Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
- Alternative Names
- PGR; NR3C3; Progesterone receptor; PR; Nuclear receptor subfamily 3group C member 3; H4 K20 HMTase; H4 K20 specific histone methyltransferase; H4-K20-HMTase SETD8; Histone H4 K20 methyltransferase; Histone lysine N methyltransferase H4 lysine 20 specific; Histone-lysine N-methyltransferase SETD8; Lysine N-methyltransferase 5A; N-lysine methyltransferase SETD8; Pr SET 7; Pr SET7; PR-Set7; PR/SET domain containing protein 07; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; PR/SET07
- Full Name
- Lysine Methyltransferase 5A
- Gene ID
- 387893
- UniProt ID
- Q9NQR1
- Sequence Similarities
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Cellular Localization
- Nucleus, Chromosome
- Post Translation Modifications
- Acetylated at Lys-162; does not affect methyltransferase activity.
Deacetylated at Lys-162 possibly by SIRT2; does not change methyltransferase activity.
( Q9NQR1-KMT5A_HUMAN )
Ubiquitinated and degraded by the DCX(DTL) complex. ( Q9NQR1-KMT5A_HUMAN )
Ubiquitination at Lys236 and Lys275 ( NX_Q9NQR1 [NX_Q9NQR1-1] )
Modification sites at PhosphoSitePlus ( Q9NQR1 )
Glycosylation from GlyGen (Q9NQR1) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047284792.1; XP_047284793.1; XP_054228016.1; XP_054228017.1; NP_001311433.1
- Function
- Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (PubMed:12086618, 12121615, 15964846, 17707234, 27338793).
Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1).
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Datasheet
MSDS
COA
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| MRO-0904-CN | Recombinant Rabbit Anti-KMT5A Monoclonal Antibody (JM73-43) | WB, FC | Rabbit IgG |
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