Anti-KPNA2 (clone W24V188) Recombinant Antibody Coupled Liposome (VS-1024-FY189)
CAT#: VS-1024-FY189
The anti-KPNA2 antibody-conjugated liposome aims to inhibit nuclear transport mechanisms critical for melanoma cell survival. KPNA2 is involved in the nuclear import of numerous proteins, including those that promote tumor growth. By disrupting this pathway, the liposome can potentially enhance the therapeutic efficacy against melanoma. Preliminary findings suggest that this approach may also help in reversing drug resistance.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41270/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/945_C8_3_selected.jpg
Normal Tissue
Figure 3 Testis
Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_4_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_8_8.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_B_7_5.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_8_4.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182481-KPNA2
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V188
- Antibody Type
- IgG2a
- Antibody Host
- Rat
- Antibody Reactivity
- Mouse
- Antibody Description
- This specially designed recombinant rat monoclonal antibody targets the KPNA2 protein, known for its role in nucleocytoplasmic transport. KPNA2 is of particular interest in numerous biological processes, including signal transduction and cell proliferation. The ability of this antibody to bind specifically to KPNA2 enhances its utility in cancer research, particularly in understanding how abnormal transport mechanisms contribute to tumor progression.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- KPNA2
- Introduction
- The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.
- Alternative Names
- QIP2; RCH1; IPOA1; PTAC58; SRP1alpha; SRP1-alpha; importin subunit alpha-1; RAG cohort protein 1 importin subunit alpha-2 importin-alpha-P1 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) nuclear pore-targeting complex 58kD component pendulin
- Full Name
- Karyopherin Subunit Alpha 2
- Gene ID
- 3838
- UniProt ID
- P52292
- Sequence Similarities
- Belongs to the importin alpha family.
- Cellular Localization
- Cytoplasm; Nucleus
- Post Translation Modifications
- Ubiquitinated.
Deubiquitinated by USP22; leading to stabilization and increased activity.
( P52292-IMA1_HUMAN )
Ubiquitination at Lys83, Lys108, Lys123, Lys240, Lys291, Lys300, Lys353, and Lys486 ( NX_P52292 [NX_P52292-1] )
Modification sites at PhosphoSitePlus ( P52292 )
Glycosylation from GlyGen (P52292) 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001307540.1; NP_002257.1
- Function
- Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, 32130408, 7604027, 7754385).
Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, 32130408, 7604027, 7754385).
Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3100z | Mouse Anti-KPNA2 Recombinant Antibody (clone 4B8) | WB, ELISA, FC, ICC, IF, IHC, ICC, IF | Mouse IgG1 |
| MRO-0906-CN | Recombinant Rabbit Anti-KPNA2 Monoclonal Antibody (JM90-33) | WB, FC | Rabbit IgG |
| VS1-YJ116 | Rat Anti-KPNA2 Recombinant Antibody (clone 2G7) | WB | Rat IgG2a |
| VS7-0425-WR247 | Mouse Anti-KPNA2 Recombinant Antibody (clone 1E8B7) | WB, IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0276MZ | Chicken Anti-Importin α2 subunit Polyclonal IgY | WB | Chicken antibody |
| BRD-1037MZ | Chicken Anti-KPNA2 Polyclonal IgY | WB | Chicken antibody |
| BRD-1038MZ | Chicken Anti-PPBP Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1972 | Hi-Affi™ Recombinant Rabbit Anti-KPNA2 Monoclonal Antibody (DS1972AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1202 | Anti-KPNA2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3822 | Anti-Human KPNA2 Immunohistochemistry Kit | IHC |
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