Mouse Anti-KRT20 Recombinant Antibody (VS-1125-XY588)
CAT#: VS-1125-XY588
This KRT20 recombinant antibody aids cell therapy by enabling targeted recognition of KRT20 - positive cancer cells, guiding therapeutic cells to specifically eliminate abnormal cells while sparing normal tissues. In companion diagnostics, it allows precise detection of KRT20 expression in tumor samples to identify patients suitable for KRT20 - directed therapies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/24684/if_selected.jpg
Normal Tissue
Figure 2 High expression in small intestine
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/24309/54018_A_5_2_val_selected.jpg
Normal Tissue
Figure 3 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/24309/54018_A_7_4_val_selected.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Gradient Gradient: Ascending Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32/127_A_8_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171431-KRT20
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Specifications
- Host Animal
- Mouse
- Applications
- WB, IHC
- Specificity
- KRT20
- Target
- KRT20
- Species Reactivity
- Human
- Type
- Mouse IgG1
- Purity
- >95%, determined by SDS-PAGE
- Purification
- Affinity chromatography
- Format
- Lyophilized
- Buffer
- PBS, pH 7.3, with 8% trehalose
- Preservative
- No Preservative
- Storage
- Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
Target
- Introduction
- Keratin 20 (KRT20) is an intermediate filament protein expressed in normal epithelial cells of the gastrointestinal tract (colon, small intestine), urothelium, and Merkel cells. It maintains cytoskeletal integrity and epithelial cell structure. KRT20 is overexpressed in colorectal cancer, bladder cancer, gastric cancer, and Merkel cell carcinoma, with minimal expression in other normal tissues. Its tissue-specific expression makes it a valuable diagnostic marker (e.g., in circulating tumor cells) and therapeutic target. Approaches include antibody-drug conjugates and peptide vaccines, targeting KRT20+ tumor cells while sparing healthy tissues, particularly in gastrointestinal and urothelial malignancies.
- Alternative Names
- CD20, CK-20, CK20, K20, KRT21
- Gene ID
- 54474
- UniProt ID
- P35900
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "KRT20"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1373z | Mouse Anti-KRT20 Recombinant Antibody (clone 27D4) | WB, ICC, IF, FC, ELISA | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2245MZ | Recombinant Mouse Anti-Human KRT20 Antibody (clone Lt30.9) | FC, IHC-P | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1985 | Hi-Affi™ Recombinant Rabbit Anti-KRT20 Monoclonal Antibody (DS1985AB) | IHC-Fr, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0444-CN | Recombinant Rabbit Anti-KRT20 Monoclonal Antibody (CBACN-182) | WB, IF, IHC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0248J | Mouse Anti-KRT20 Recombinant Antibody (ZG-0248J) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-1052F | Mouse Anti-KRT20 Recombinant Antibody (clone MKs20-8) | IHC-Fr, IHC-P, IP, WB, ICC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1216 | Anti-KRT20 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3867 | Anti-Rat KRT20 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3866 | Anti-Human KRT20 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY589 | Mouse Anti-KRT20 Recombinant Antibody (VS-1125-XY589) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY590 | Mouse Anti-KRT20 Recombinant Antibody (VS-1125-XY590) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY591 | Mouse Anti-KRT20 Recombinant Antibody (VS-1125-XY591) | WB, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY592 | Mouse Anti-KRT20 Recombinant Antibody (VS-1125-XY592) | WB, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY593 | Mouse Anti-KRT20 Recombinant Antibody (VS-1125-XY593) | WB, IHC | Mouse IgG2b |
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