Mouse Anti-KRT5 Monoclonal Antibody (VS7-0425-WR266) (CAT#: VS7-0425-WR266)
This product is a mouse IgG antibody that binds to human KRT5. The antibody can be used for WB, IHC-P, IF, ICC, and ELISA assays.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line hTCEpi
(Immunofluorescent staining of human cell line hTCEpi shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59479/1790_D3_5_selected.jpg
(Immunofluorescent staining of human cell line hTCEpi shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59479/1790_D3_5_selected.jpg
Figure 2 High expression in skin 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59479/133810_B_7_1_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59479/133810_B_7_1_selected.jpg
Figure 3 Low expression in skeletal muscle
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59479/133810_B_2_6_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59479/133810_B_2_6_val_selected.jpg
Figure 4 Skin
(Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Eccrine glands Staining: High Intensity: Strong Quantity:>75% Hair follicles Staining: High Intensity: Strong Quantity: 75%-25% Sebaceous glands Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59479/133810_B_7_1.jpg
(Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Eccrine glands Staining: High Intensity: Strong Quantity:>75% Hair follicles Staining: High Intensity: Strong Quantity: 75%-25% Sebaceous glands Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59479/133810_B_7_1.jpg
Figure 5 RNA cell line category: Group enriched (HaCaT, HBEC3-KT, hTCEpi)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186081-KRT5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186081-KRT5
Specifications
- Immunogen
- Recombinant human KRT5 fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human KRT5
- Species Reactivity
- Human
- Molecule Class
- Type II Cytokeratins
- Applications
- WB, IHC-P, IF, ICC, ELISA
- Conjugate
- Unconjugated
- Related Disease
- Epidermolysis bullosa simplex 2A, generalized severe (EBS2A); Epidermolysis bullosa simplex 2B, generalized intermediate (EBS2B); Epidermolysis bullosa simplex 2C, localized (EBS2C); Epidermolysis bullosa simplex 2D, generalized, intermediate or severe, autosomal recessive (EBS2D); Epidermolysis bullosa simplex 2E, with migratory circinate erythema (EBS2E); Epidermolysis bullosa simplex 2F, with mottled pigmentation (EBS2F); Dowling-Degos disease 1 (DDD1)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- 1 mg/ml
- Preservative
- 0.03% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunofluorescence: 1:200 - 1:1000
Enzyme-linked Immunosorbent Assay: 1:10000
Immunohistochemistry: 1:200 - 1:1000
Target
- Alternative Names
- KRT5; KRT5A; Keratin 5; EBS2; Cytokeratin-5; CK5; DDD1; K5; Keratin 5 (Epidermolysis Bullosa Simplex, Dowling-Meara/Kobner/Weber-Cockayne Types); 58 Kda Cytokeratin; Keratin, Type II Cytoskeletal 5; Keratin-5; Keratin 5, Type II; Type-II Keratin Kb5; Epid
- Gene ID
- 3852
- UniProt ID
- P13647
- Long Name
- Keratin 5
- Cellular Localization
- Cytoplasm; Intermediate filament; Keratin
- Post Translation Modifications
- Phosphoprotein
- Protein Refseq
- NP_000415.2
- Function
- Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity).; Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1990 | Hi-Affi™ Recombinant Rabbit Anti-KRT5 Monoclonal Antibody (DS1990AB) | IHC-P | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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