Human Anti-L1CAM Recombinant Antibody (clone cA10-A3) (CAT#: HPAB-0562-YJ)
This product is a recombinant chimeric (mouse/human) antibody that recognizes (both natural and recombinant) human L1CAM. It is capable of effectively controlling the proliferation of cancer cells.
Specific Inquiry
ELISA
Figure 1. Affinity determination of anti-L1CAM mAbs. Antigen-binding activities of A10-A3 (•) and cA10-A3 (▽) were determined by indirect ELISA.
Lee, E. S., Jeong, M. S., Singh, R., Jung, J., Yoon, H., Min, J. K., ... & Hong, H. J. (2012). A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model. Experimental & molecular medicine, 44(4), 293-302.
Inhib
Figure 2. Inhibition of ICC tumor growth in nude mice by cA10-A3 treatment.
cA10-A3 antibody or the isotype control Synagis was intravenously injected at a dose of 10 mg/kg three times a week for 28 days in nude mice bearing Choi-CK xenograft.
Lee, E. S., Jeong, M. S., Singh, R., Jung, J., Yoon, H., Min, J. K., ... & Hong, H. J. (2012). A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model. Experimental & molecular medicine, 44(4), 293-302.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric (mouse/human) IgG
- Specificity
- Human L1CAM
- Species Reactivity
- Human
- Clone
- cA10-A3
- Applications
- ELISA, Inhib
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The cA10-A3 antibody has been reported in applications of Inhib, ELISA.
It's recommended that the optimal antibody concentration, dilution, incubation time etc. are best to be carefully titrated in specific assays. For details, refer to Published Data.
ELISA: Microtiter wells were coated with the purified hL1-ECD-S1 (100 ng) diluted in 50 mM sodium carbonate buffer (pH 9.6) at 4°C overnight and blocked with skim milk (2%) in PBS. The plates were washed four times with PBST (PBS containing 0.05% Tween 20) between steps. A10-A3 or cA10-A3 (0-100 ng) was added to each well, then antimouse IgG-HRP or anti-human Fc-HRP (Thermo, 1:10,000 v/v) was added to the wells.
Target
- Alternative Names
- S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1; neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1
- Gene ID
- 3897
- UniProt ID
- P32004
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0635CL | Human Anti-L1CAM Recombinant Antibody (TAB-0635CL) | WB, IF, IHC, PK, ELISA, FC | Human antibody |
| TAB-0635CL-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (TAB-0635CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0635CL-F(E) | Human Anti-L1CAM Recombinant Antibody; Fab Fragment (TAB-0635CL-F(E)) | ELISA, FC | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0636CL | Anti-Human L1CAM Recombinant Antibody (L1-9.3) | WB, IHC, ELISA, FC | |
| TAB-0636CL-S(P) | Anti-Human L1CAM Recombinant Antibody scFv Fragment (L1-9.3) | WB, FC | |
| TAB-0636CL-F(E) | Anti-Human L1CAM Recombinant Antibody Fab Fragment (L1-9.3) | WB, FC |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0910CT | Recombinant Mouse anti-Human L1CAM Monoclonal antibody (6H4) | FC | |
| FAMAB-0191YC | Human Anti-L1CAM Recombinant Antibody (clone G6) | ELISA, IF, WB | Human IgG |
| FAMAB-0192YC | Human Anti-L1CAM Recombinant Antibody (clone H2) | ELISA, IF, WB | Human IgG |
| MRO-2060-CN | Rabbit Anti-L1CAM Polyclonal Antibody (MRO-2060-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-J0160-YC | Human Anti-L1CAM Recombinant Antibody (clone Ab4) | FC, Inhib, FuncS | Human IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1999 | Hi-Affi™ Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (DS1999AB) | ELISA, WB | IgG |
| MOR-4297 | Hi-Affi™ Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (SI384DS) | FC | IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0398-CN-S(P) | Mouse Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0398-CN-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
| HPAB-0827-CN-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0827-CN-S(P)) | WB, ELISA, IHC, FC | Human scFv |
| HPAB-0828-CN-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0828-CN-S(P)) | WB, ELISA, IHC, FC | Human scFv |
| HPAB-J0160-YC-S(P) | Human Anti-L1CAM Recombinant Antibody (clone Ab4); scFv Fragment | ELISA, FC, WB, FuncS | Human scFv |
| HPAB-0561-YJ-S(P) | Mouse Anti-L1CAM Recombinant Antibody (clone A10-A3); scFv Fragment | ELISA, FC, FuncS | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0191-YC-F(E) | Human Anti-L1CAM Recombinant Antibody (clone G6); Fab Fragment | ELISA, IF, WB | Human Fab |
| FAMAB-0192-YC-F(E) | Human Anti-L1CAM Recombinant Antibody (clone H2); Fab Fragment | ELISA, IF, WB | Human Fab |
| HPAB-0827-CN-F(E) | Human Anti-L1CAM Recombinant Antibody; Fab Fragment (HPAB-0827-CN-F(E)) | WB, ELISA, IHC, FC | Human Fab |
| HPAB-0828-CN-F(E) | Human Anti-L1CAM Recombinant Antibody; Fab Fragment (HPAB-0828-CN-F(E)) | WB, ELISA, IHC, FC | Human Fab |
| HPAB-J0160-YC-F(E) | Human Anti-L1CAM Recombinant Antibody (clone Ab4); Fab Fragment | ELISA, FC, WB, FuncS | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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