Mouse Anti-LAMB1 Monoclonal Antibody (VS7-0425-WR279)
CAT#: VS7-0425-WR279
This product is a mouse IgG antibody that binds to human LAMB1. The antibody recognizes specific amino acid domain of Laminin Beta-1 (aa31-270). It can be used for WB, IHC-P, IF, and ELISA assays.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_2_7_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Low expression. RNA expression: 5.2 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4132/12669_A_4_8_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranou
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Enterocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HSkMC, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091136-LAMB1
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Specifications
- Immunogen
- Recombinant Laminin Beta-1 (aa31-270) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human LAMB1
- Species Reactivity
- Human
- Molecule Class
- Heterotrimeric Laminin Protein Family
- Applications
- WB, IHC-P, IF, ELISA
- Conjugate
- Unconjugated
- Related Disease
- Lissencephaly 5 (LIS5)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- 1 mg/ml
- Preservative
- 0.03% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunohistochemistry: 1:200 - 1:1000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- LAMB1; Cutis Laxa With Marfanoid Phenotype; Laminin-1 Subunit Beta; Laminin-10 Subunit Beta; Laminin-2 Subunit Beta; Laminin-12 Subunit Beta; Laminin-6 Subunit Beta; Laminin, Beta 1; Laminin-8 Subunit Beta; Laminin B1 Chain; LIS5; Laminin Subunit Beta-1
- Gene ID
- 3912
- UniProt ID
- P07942
- Long Name
- Laminin subunit beta 1
- Cellular Localization
- Basement membrane; Extracellular matrix; Secreted
- Post Translation Modifications
- Disulfide bond; Glycoprotein; Phosphoprotein
- Protein Refseq
- NP_002282.2
- Function
- Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3926 | Anti-LAMB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3927 | Anti-Mouse LAMB1 Immunohistochemistry Kit | IHC |
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