Rat Anti-Laminin Recombinant Antibody (clone Hg15) (CAT#: FAMAB-0199YC)

Because of their staining pattern on normal kidney sections and their reactivity to a panel of renal proteins, the antibody MEC2 can be considered as a set of Abs representative for the autoreactive antibodies within the glomerular eluate of HgCl2-diseased rats. The binding of clone Hg15 to laminin is highly specific.


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IF

Figure 1 Direct immunofluorescence andpost-embedding immunoelectron microscopy on renal tissue upon intravenous passive transfer into naive DZB rats of monoclonal autoantibodies, derived from HgCl<sub>2</sub>-treated rats.

Figure 1 Direct immunofluorescence andpost-embedding immunoelectron microscopy on renal tissue upon intravenous passive transfer into naive DZB rats of monoclonal autoantibodies, derived from HgCl2-treated rats.

At day 14 upon passive transfer of Hgl5, IgG1 was detected in a linear pattern along GBM, TBM, and vessel walls (X310).

Aten, J., Veninga, A., Coers, W., Sonnenberg, A., Timpl, R., Claessen, N., van Eendenburg, J. D., de Heer, E., & Weening, J. J. (1995). Autoantibodies to the laminin P1 fragment in HgCl2-induced membranous glomerulopathy. The American journal of pathology, 146(6), 1467–1480.


Specifications

  • Host Species
  • Rat
  • Type
  • Rat IgG1
  • Specificity
  • Rat Laminin
  • Species Reactivity
  • Rat
  • Clone
  • Hg15
  • Applications
  • IHC

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Laminin; Basal lamina

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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