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    CytoStream™ Rabbit Anti-LMNA Recombinant Antibody (VS13-YC665) (CAT#: VS13-YC665)

    The CytoStream™ Rabbit Anti-LMNA Recombinant Antibody is specific for human, mouse and rat LMNA. LMNA forms part of nuclear lamina, involved in nuclear stability, chromatin structure, and expression. Mutations link to disorders like muscular dystrophy and progeria. The anti-LMNA antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line PC-3
    Figure 1 IF staining of human cell line PC-3
    (Immunofluorescent staining of human cell line PC-3 shows localization to nuclear speckles.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6523/1905_E12_1_selected.jpg
    Figure 2 IHC staining of human epididymis
    Figure 2 IHC staining of human epididymis
    (Immunohistochemical staining of human epididymis shows strong nuclear membrane positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6660/ihc_selected.jpg
    Figure 3 IHC staining of human rectum
    Figure 3 IHC staining of human rectum
    (Immunohistochemical staining of human rectum shows strong nuclear membrane positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/ihc_selected.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Glial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Neuronal cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_B_8_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endocrine cells
    Staining: High
    Intensity: Strong
    Endothelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Enterocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Enterocytes - Microvilli
    Staining: High
    Intensity: Strong
    Fibroblasts
    Staining: High
    Intensity: Strong
    Goblet cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Mucosal lymphoid cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_9_3.jpg
    Figure 6 Liver
    Figure 6 Liver
    (Cholangiocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Hepatocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_7_4.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Cells in tubules
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_8_5.jpg
    Figure 8 Testis
    Figure 8 Testis
    (Leydig cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Peritubular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Sertoli cells
    Staining: High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_6_6.jpg
    Figure 9 Skin
    Figure 9 Skin
    (Cells in basal layer
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Cells in granular layer
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Cells in spinous layer
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Endothelial cells
    Staining: High
    Intensity: Strong
    Fibrohistiocytic cells
    Staining: High
    Intensity: Strong
    Langerhans cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_B_9_1.jpg
    Figure 10 Lymph node
    Figure 10 Lymph node
    (Germinal center cells
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_7_8.jpg
    RNA Expression
    Figure 11 RNA cell line category: Low cell line specificity
    Figure 11 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160789-LMNA

    Specifications

    • Immunogen
    • Recombinant human Lamin A/C, aa 191-309.
    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human, Mouse and Rat LMNA
    • Species Reactivity
    • Human, Mouse, Rat
    • Applications
    • WB, ICC, IF, IHC-P, FC
    • Conjugate
    • NONE
    • Related Disease
    • Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome

    Product Property

    • Clonality
    • Monoclonal
    • Purification
    • Protein A purified
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
    • Preservative
    • 0.05% Sodium azide
    • Storage
    • Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Shipping with ice pack.

    Applications

    • Application Notes
    • Western blot (WB): 1/500-1/2000
      Immunocytochemistry (ICC): 1/50-1/100
      Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
      Flow cytometry (FC): 1/50-1/100

    Target

    • Alternative Names
    • HGPS, MADA
    • Long Name
    • Lamin A/C
    • Cellular Localization
    • Nucleus; Intermediate filament

    Recommended Products

    Secondary Antibody

    Isotype Control

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "LMNA"

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    CAT Product Name Application Type
    MOB-1798z Mouse Anti-LMNA Recombinant Antibody (clone 12B7) ICC, IF, IHC Mouse IgG3
    MOB-1769MZ Recombinant Mouse Anti-Human LMNA Antibody (clone KPM3) FC, ICC/IF, IHC-Fr, IHC-P, IP, WB Mouse antibody
    ZG-0446U Rabbit Anti-LMNA Recombinant Antibody (clone 4H7) ELISA, IHC, IF, FC, IP Rabbit IgG
    VS1-YJ190 Mouse Anti-LMNA Recombinant Antibody (clone 13A4D4) WB, ICC, IF, IP Mouse IgG1, κ
    VS3-CJ299 Mouse Anti-LMNA Recombinant Antibody (VS3-CJ299) WB Mouse IgG1, κ

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