CytoStream™ Rabbit Anti-LMNA Recombinant Antibody (VS13-YC665)
CAT#: VS13-YC665
The CytoStream™ Rabbit Anti-LMNA Recombinant Antibody is specific for human, mouse and rat LMNA. LMNA forms part of nuclear lamina, involved in nuclear stability, chromatin structure, and expression. Mutations link to disorders like muscular dystrophy and progeria. The anti-LMNA antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nuclear speckles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6523/1905_E12_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human epididymis
Immunohistochemical staining of human epididymis shows strong nuclear membrane positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6660/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong nuclear membrane positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endocrine cells
Staining: High
Intensity: Strong
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Fibroblasts
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_7_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peritubular cells
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_6_6.jpg
Normal Tissue
Figure 9 Skin
Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in granular layer
Staining: High
Intensity: Strong
Quantity: 75%-25%
Cells in spinous layer
Staining: High
Intensity: Strong
Quantity: 75%-25%
Endothelial cells
Staining: High
Intensity: Strong
Fibrohistiocytic cells
Staining: High
Intensity: Strong
Langerhans cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_B_9_1.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_7_8.jpg
RNA Expression
Figure 11 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160789-LMNA
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Specifications
- Immunogen
- Recombinant human Lamin A/C, aa 191-309.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LMNA
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, IF, IHC-P, FC
- Conjugate
- NONE
- Related Disease
- Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/2000
Immunocytochemistry (ICC): 1/50-1/100
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "LMNA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0327MZ | Chicken Anti-LMNA Polyclonal IgY | WB | Chicken antibody |
| BRD-1186MZ | Chicken Anti-Lamin A/C Polyclonal IgY | N/A | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2067 | Hi-Affi™ Recombinant Rabbit Anti-LMNA Monoclonal Antibody (DS2067AB) | FC, ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1922 | PE-A*02:01/Human LMNA (RLAVYIDRV) MHC Tetramer | FCM | |
| MHC-CN0129 | APC-B*58:01/Human Lamin (KAGQVVTIW) MHC Tetramer | FCM | |
| MHC-CN0130 | PE-B*58:01/Human Lamin (KAGQVVTIW) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0958F | Mouse Anti-LMNA Recombinant Antibody (clone 131C3) | FC, ICC, IHC-Fr | Mouse IgG1 |
| ZG-0960F | Mouse Anti-LMNA Recombinant Antibody (clone 133A2) | FC, ICC, IHC-Fr | Mouse IgG3 |
| VS1-YJ190 | Mouse Anti-LMNA Recombinant Antibody (clone 13A4D4) | WB, ICC, IF, IP | Mouse IgG1, κ |
| VS3-FY850 | Recombinant Rabbit Anti-LMNA Antibody (clone R06-7H5) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
| VS3-FY851 | Recombinant Rabbit Anti-LMNA Antibody (clone R07-1I5) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY175 | AbPlus™ Anti-LMNA Magnetic Beads (13A4D4) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4051 | Anti-LMNA Immunohistochemistry Kit | IHC | |
| VS-0525-XY4052 | Anti-Mouse LMNA Immunohistochemistry Kit | IHC |
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