Rabbit Anti-LMNB1 Recombinant Antibody (VS13-YC666) (CAT#: VS13-YC666)
The Rabbit Anti-LMNB1 Recombinant Antibody is specific for human, mouse and rat LMNB1. LMNB1 encodes B-type lamin proteins, part of the nuclear lamina, with duplication leading to leukodystrophy. The anti-LMNB1 antibody can be used for Western blot (1/500-1/1000), Immunocytochemistry (1/50-1/200), Immunofluorescence (1/50-1/200), Immunohistochemistry-paraffin (1/100-1/500).
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/if_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/if_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5269/950_C1_1_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5269/950_C1_1_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79757/1894_G3_4_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79757/1894_G3_4_selected.jpg
Figure 4 IHC staining of human colon
(Immunohistochemical staining of human colon shows nuclear membrane positivity in glandular and stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/ihc_selected.jpg
(Immunohistochemical staining of human colon shows nuclear membrane positivity in glandular and stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/ihc_selected.jpg
Figure 5 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong nuclear membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5269/155655_A_3_1_selected.jpg
(Immunohistochemical staining of human stomach shows strong nuclear membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5269/155655_A_3_1_selected.jpg
Figure 6 IHC staining of human esophagus
(Immunohistochemical staining of human esophagus shows strong nuclear positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79954/171056_B_6_1_selected.jpg
(Immunohistochemical staining of human esophagus shows strong nuclear positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79954/171056_B_6_1_selected.jpg
Figure 7 Cerebral cortex
(Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/140330_B_8_5.jpg
(Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/140330_B_8_5.jpg
Figure 8 Kidney
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/140330_A_7_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/140330_A_7_4.jpg
Figure 9 Testis
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/140330_A_5_6.jpg
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/140330_A_5_6.jpg
Figure 10 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/140330_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50524/140330_A_8_8.jpg
Figure 11 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113368-LMNB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113368-LMNB1
Specifications
- Immunogen
- Recombinant human Lamin B1, aa 511-560.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LMNB1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, IF, IHC-P, IP
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/100-1/500
Target
- Alternative Names
- LMN2, LMNB
- Gene ID
- 4001
- UniProt ID
- P20700
- Long Name
- Lamin B1
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Nucleus inner membrane; Intermediate filament
- Protein Refseq
- NP_005564.1
- Function
- Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1818z | Mouse Anti-LMNB1 Recombinant Antibody (clone 19G6) | ELISA, IHC, WB | Mouse IgG2a, κ |
| MOB-2469CT | Recombinant Mouse anti-Chicken LMNB1 Monoclonal antibody (T70) | WB | |
| MOB-0073F | Mouse Anti-LMNB1 Recombinant Antibody (clone 7C11) | WB, IHC-P, IF, IP | Mouse IgG |
| ZG-0953F | Mouse Anti-LMNB1 Recombinant Antibody (clone 119D5-F1) | FC, ICC, WB, IHC-Fr, ELISA | Mouse IgG1 |
| VS3-CJ772 | Rabbit Anti-LMNB1 Recombinant Antibody (VS3-CJ772) | WB, ICC, IF, IHC, IP | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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