Rabbit Anti-LRP2 Recombinant Antibody (clone R02-7D4)
CAT#: VS3-XY3420
The product is a recombinant rabbit antibody that recognizes LRP2 (LDL receptor related protein 2), which mediates receptor-mediated uptake of polybasic drugs. It is capable of binding to human, mouse and rat LRP2. It has been used in a variety of applications, such as Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
High expression. RNA expression: 34.8 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human lymph node
Low expression. RNA expression: 0.0 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_8_8_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_B_9_5.jpg
Normal Tissue
Figure 5 Parathyroid gland
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_3_8.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (AF22, CACO-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081479-LRP2
❮
❯
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LRP2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R02-7D4
- Applications
- WB
- Related Disease
- Donnai-Barrow Syndrome; Non-Syndromic Syndactyly
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- DBS; GP330; LRP-2
- Gene ID
- 4036
- UniProt ID
- P98164
- Long Name
- LDL receptor related protein 2
- Sequence Similarities
- Belongs to the LDLR family.
- Cellular Localization
- Cell membrane, Cell projection, Coated pit, Endosome, Membrane
- Post Translation Modifications
- A fraction undergoes proteolytic cleavage of the extracellular domain at the cell membrane to generate a cytoplasmic tail fragment. This is internalized into the early endosome from where it trafficks in an LDLRAP1/ARH-dependent manner to the endocytic recycling compartment (ERC). In the ERC, it is further cleaved by gamma-secretase to release a fragment which translocates to the nucleus and mediates transcriptional repression.
- Protein Refseq
- NP_004516.2
- Function
- Multiligand endocytic receptor (By similarity).
Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity).
Mediates receptor-mediated uptake of polybasic drugs such as aminoglycosides and polymyxin B (By similarity).
In the kidney, mediates the tubular uptake and clearance of leptin (By similarity).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-XY3420. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "LRP2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1789z | Mouse Anti-LRP2 Recombinant Antibody (clone 44H10) | ICC, IF, IHC | Mouse IgG1 |
| MOB-048CQ | Rabbit Anti-Human LRP2 Polyclonal Antibody | ELISA, WB | Rabbit IgG |
| VS4-CJ20 | Recombinant Rabbit Anti-LRP2 Antibody (clone 10B5) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2086 | Hi-Affi™ Recombinant Rabbit Anti-LRP2 Monoclonal Antibody (DS2086AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1269 | Anti-LRP2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4096 | Anti-Mouse LRP2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4095 | Anti-Human LRP2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4097 | Anti-Rat LRP2 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FC, IHC, FuncS, Inhib, Cyt
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FC, ADCC, CDC, Inhib
Application: ELISA, Inhib, FuncS
Application: ELISA, PD, Activ, PK, Stim
Application: ELISA, Vaccine, FuncS
Application: ELISA, WB, IF, FC, IP
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
