Rabbit Anti-LRP2 Recombinant Antibody (clone R02-7D4) (CAT#: VS3-XY3420)
The product is a recombinant rabbit antibody that recognizes LRP2 (LDL receptor related protein 2), which mediates receptor-mediated uptake of polybasic drugs. It is capable of binding to human, mouse and rat LRP2. It has been used in a variety of applications, such as Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/if_selected.jpg
Figure 2 IHC staining of human kidney
(High expression. RNA expression: 34.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/ihc_selected.jpg
(High expression. RNA expression: 34.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/ihc_selected.jpg
Figure 3 IHC staining of human lymph node
(Low expression. RNA expression: 0.0 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_8_8_val_selected.jpg
(Low expression. RNA expression: 0.0 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_8_8_val_selected.jpg
Figure 4 Cerebral cortex
(Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_B_9_5.jpg
(Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_B_9_5.jpg
Figure 5 Parathyroid gland
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_3_8.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_3_8.jpg
Figure 6 Liver
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_9_4.jpg
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_9_4.jpg
Figure 7 Kidney
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_7_5.jpg
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64792/146056_A_7_5.jpg
Figure 8 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_4_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5980/18216_A_4_6.jpg
Figure 9 RNA cell line category: Group enriched (AF22, CACO-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081479-LRP2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081479-LRP2
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LRP2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R02-7D4
- Applications
- WB
- Related Disease
- Donnai-Barrow Syndrome; Non-Syndromic Syndactyly
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- DBS; GP330; LRP-2
- Gene ID
- 4036
- UniProt ID
- P98164
- Long Name
- LDL receptor related protein 2
- Sequence Similarities
- Belongs to the LDLR family.
- Cellular Localization
- Cell membrane, Cell projection, Coated pit, Endosome, Membrane
- Post Translation Modifications
- A fraction undergoes proteolytic cleavage of the extracellular domain at the cell membrane to generate a cytoplasmic tail fragment. This is internalized into the early endosome from where it trafficks in an LDLRAP1/ARH-dependent manner to the endocytic recycling compartment (ERC). In the ERC, it is further cleaved by gamma-secretase to release a fragment which translocates to the nucleus and mediates transcriptional repression.
- Protein Refseq
- NP_004516.2
- Function
- Multiligand endocytic receptor (By similarity).
Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity).
Mediates receptor-mediated uptake of polybasic drugs such as aminoglycosides and polymyxin B (By similarity).
In the kidney, mediates the tubular uptake and clearance of leptin (By similarity).
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
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| MOB-1789z | Mouse Anti-LRP2 Recombinant Antibody (clone 44H10) | ICC, IF, IHC | Mouse IgG1 |
| MOB-048CQ | Rabbit Anti-Human LRP2 Polyclonal Antibody | ELISA, WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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