Mouse Anti-LRP6 Recombinant Antibody (clone 1A3F5)
CAT#: VS7-0425-WR317
This product is a mouse IgG1 antibody that binds to human LRP6. The antibody 1A3F5 recognizes specific amino acid domain of human LRP6 (AA: extra 1198-1370). It can be used for FC assay.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
High expression. RNA expression: 4.4 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human lymph node
Low expression. RNA expression: 0.8 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/62204_A_7_8_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12171_B_8_5.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_8_4.jpg
Normal Tissue
Figure 6 Testis
Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070018-LRP6
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Specifications
- Immunogen
- Recombinant human LRP6 (AA: extra 1198-1370) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human LRP6
- Species Reactivity
- Human
- Clone
- 1A3F5
- Molecule Class
- Low-Density Lipoprotein Receptor (LDLR)
- Applications
- FC
- Conjugate
- Unconjugated
- Related Disease
- Coronary artery disease, autosomal dominant, 2 (ADCAD2); Tooth agenesis, selective, 7 (STHAG7)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- LRP6; LRP-6; Low-Density Lipoprotein Receptor-Related Protein 6; Low Density Lipoprotein Receptor-Related Protein 6
- Gene ID
- 4040
- UniProt ID
- O75581
- Long Name
- LDL receptor related protein 6
- Cellular Localization
- Cell membrane; Endoplasmic reticulum; Membrane
- Post Translation Modifications
- Disulfide bond; Glycoprotein; Isopeptide bond; Lipoprotein; Palmitate; Phosphoprotein; Ubl conjugation
- Protein Refseq
- NP_001401173.1
- Function
- Developmental protein; Receptor
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Hepatocellular Carcinoma
Pancreatic Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| HPAB-0649-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0649-WJ-S(P)) | ELISA | Human scFv |
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