Mouse Anti-LRP6 Recombinant Antibody (clone 1A3F5) (CAT#: VS7-0425-WR317)
This product is a mouse IgG1 antibody that binds to human LRP6. The antibody 1A3F5 recognizes specific amino acid domain of human LRP6 (AA: extra 1198-1370). It can be used for FC assay.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IHC staining of human colon
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg
Figure 2 IHC staining of human kidney
(High expression. RNA expression: 4.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/ihc_selected.jpg
(High expression. RNA expression: 4.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/ihc_selected.jpg
Figure 3 IHC staining of human lymph node
(Low expression. RNA expression: 0.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/62204_A_7_8_val_selected.jpg
(Low expression. RNA expression: 0.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/62204_A_7_8_val_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12171_B_8_5.jpg
(Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12171_B_8_5.jpg
Figure 5 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_8_4.jpg
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_8_4.jpg
Figure 6 Testis
(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_4_6.jpg
(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_4_6.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070018-LRP6
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070018-LRP6
Specifications
- Immunogen
- Recombinant human LRP6 (AA: extra 1198-1370) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human LRP6
- Species Reactivity
- Human
- Clone
- 1A3F5
- Molecule Class
- Low-Density Lipoprotein Receptor (LDLR)
- Applications
- FC
- Conjugate
- Unconjugated
- Related Disease
- Coronary artery disease, autosomal dominant, 2 (ADCAD2); Tooth agenesis, selective, 7 (STHAG7)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- LRP6; LRP-6; Low-Density Lipoprotein Receptor-Related Protein 6; Low Density Lipoprotein Receptor-Related Protein 6
- Gene ID
- 4040
- UniProt ID
- O75581
- Long Name
- LDL receptor related protein 6
- Cellular Localization
- Cell membrane; Endoplasmic reticulum; Membrane
- Post Translation Modifications
- Disulfide bond; Glycoprotein; Isopeptide bond; Lipoprotein; Palmitate; Phosphoprotein; Ubl conjugation
- Protein Refseq
- NP_001401173.1
- Function
- Developmental protein; Receptor
Recommended Products
Isotype Control
Secondary Antibody
Reconstitution Buffer
Recommended Dilution Buffer
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2487z | Mouse Anti-LRP6 Recombinant Antibody (clone 25B10) | WB, ELISA, IF, IHC, IP | Mouse IgG2a, κ |
| PABC-205 | Mouse Anti-LRP6 Recombinant Antibody (PABC-205) | FC, WB, FuncS, IF, Inhib | Mouse IgG |
| HPAB-0647-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0647-WJ) | ELISA | Human IgG |
| HPAB-0648-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0648-WJ) | ELISA | Human IgG |
| VS3-WK2089 | Rabbit Anti-LRP6 (pS1490) Recombinant Antibody (clone R76-2O-7) | WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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