Does this antibody inhibit Wnt signaling?

Yes, this Recombinant Human Antibody binds to the beta-propeller 1 domain of LRP6 and blocks Propeller 1-dependent Wnts. Consequently, the antibody inhibits the Wnt signaling pathway, making it a key tool for signal transduction research.

What is the target specificity of this antibody?

This antibody specifically recognizes Human LRP6 (low density lipoprotein-related protein 6). LRP6 functions as a receptor or coreceptor for Wnt and is crucial for the canonical Wnt/beta-catenin signaling cascade.

Human Anti-LRP6 Recombinant Antibody (HPAB-0648-WJ)

CAT#: HPAB-0648-WJ

This product is a recombinant human antibody that recognizes LRP6 (low density lipoprotein-related protein 6). It can bind to the β-propeller 1 domain of LRP6 and block Propeller 1-dependent Wnts. The antibody inhibits the Wnt signaling pathway.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IHC staining of human colon

Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg

Normal Tissue Figure 2 IHC staining of human kidney

High expression. RNA expression: 4.4 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/ihc_selected.jpg

Normal Tissue Figure 3 IHC staining of human lymph node

Low expression. RNA expression: 0.8 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/62204_A_7_8_val_selected.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12171_B_8_5.jpg

Normal Tissue Figure 5 Liver

Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_8_4.jpg

Normal Tissue Figure 6 Testis

Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_4_6.jpg

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070018-LRP6

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Specifications

Host Species
Human

Type
Human IgG

Specificity
Human LRP6

Species Reactivity
Human

Applications
ELISA

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
LRP6; low density lipoprotein receptor-related protein 6; ADCAD2; low-density lipoprotein receptorrelated protein 6; LRP-6

Gene ID
4040

UniProt ID
O75581

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Breast cancer biomarkers at key points during disease progression

Blocks Wnt Signaling

This antibody specifically binds the beta-propeller 1 domain of LRP6 and we confirmed it blocks Wnt signaling in our reporter assays. It is a powerful tool for dissecting the Wnt/beta-catenin pathway.

Specific For LRP6

We used this in ELISA to detect LRP6 levels. The binding was specific and robust. It is helpful for our research into cell differentiation and proliferation where this receptor plays a key role.

Q&As

Does this antibody inhibit Wnt signaling?

A: Yes, this Recombinant Human Antibody binds to the beta-propeller 1 domain of LRP6 and blocks Propeller 1-dependent Wnts. Consequently, the antibody inhibits the Wnt signaling pathway, making it a key tool for signal transduction research.
What is the target specificity of this antibody?

A: This antibody specifically recognizes Human LRP6 (low density lipoprotein-related protein 6). LRP6 functions as a receptor or coreceptor for Wnt and is crucial for the canonical Wnt/beta-catenin signaling cascade.

View the frequently asked questions answered by Creative Biolabs Support.

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Related Signaling Pathways

Canonical Wnt Signaling Pathway

JAK-STAT Signaling Pathway

Non-Canonical Wnt Signaling Pathway

Related Diseases

Hepatocellular Carcinoma

Pancreatic Cancer

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0648-WJ.pdf

MSDS

MSDS - HPAB-0648-WJ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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