Rabbit Anti-LTF Recombinant Antibody (clone R03-8H9) (CAT#: VS3-XY3422)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human LTF

• Species Reactivity
• Human

• Clone
• R03-8H9

• Applications
• WB, IHC-P, IP

• Related Disease
• Mastitis; Keratoconjunctivitis Sicca

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IP: 1/20

• Alternative Names
• LF; HLF2; GIG12; HEL110

• Gene ID
• 4057

• UniProt ID
• P02788

• Long Name
• Lactotransferrin

• Cellular Localization
• Secreted, Cytoplasmic granule

• Post Translation Modifications
• Poly-N-acetyllactosaminic carbohydrate moiety seems to be needed for TLR4 activation. (P02788-TRFL_HUMAN)
  Glycosylation at Ser54, Asn156, Ser436, Asn497, and Asn642 (NX_P02788 [NX_P02788-1])
  Ubiquitination at Lys423 and Lys435 (NX_P02788 [NX_P02788-1])
  Modification sites at PhosphoSitePlus (P02788)
  Glycosylation from GlyConnect TRFL_HUMAN (2842, 320)
  Glycosylation from GlyGen (P02788) 5 sites, 158 N-linked glycans (4 sites), 2 O-linked glycans (1 site)

• Protein Refseq
• NP_001308050.1; NP_001186078.1

• Function
• Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. TRFL_HUMAN,P02788
  [Lactotransferrin]: Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions.
  Has antimicrobial activity, which depends on the extracellular cation concentration.
  Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane.
  Can also prevent bacterial biofilm development in P.aeruginosa infection.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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