Mouse Anti-LTF Recombinant Antibody (VS3-CJ316)
CAT#: VS3-CJ316
This product is a mouse antibody that recognizes LTF.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (RPMI-8226, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012223-LTF
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Specifications
- Immunogen
- Synthetic peptide
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human LTF
- Species Reactivity
- Human
- Applications
- IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50% Glycerol, PBS, pH7.4.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry (1:50-1:300).
Target
- Alternative Names
- LF; Lactotransferrin; Lactoferrin; Talalactoferrin; HLF2; GIG12; HEL110
- Gene ID
- 4057
- UniProt ID
- P02788
- Sequence Similarities
- Belongs to the transferrin family.
- Cellular Localization
- Cytoplasm, Nucleus, Secreted
- Post Translation Modifications
- Isoform DeltaLf:
Phosphorylation at Ser-10 activates the transcriptional activity (PubMed:20404350).
Phosphorylation at Ser-10 also promotes proteasomal degradation (PubMed:20404350).
Alternatively can undergo O-GlcNAcylation at Ser-10 (PubMed:20404350).
Isoform DeltaLf:
O-GlcNAcylation at Ser-10 inhibits DNA binding and negatively regulates the transcriptional activity (PubMed:20404350).
Alternatively can undergo phosphorylation at Ser-10 (PubMed:20404350).
Poly-N-acetyllactosaminic carbohydrate moiety seems to be needed for TLR4 activation.
- Protein Refseq
- NP_001186078.1; NP_001308050.1; NP_001308051.1
- Function
- Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.
Lactotransferrin: Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions (PubMed:14573629, PubMed:1599934, PubMed:6802759, PubMed:3169987, PubMed:11179314, PubMed:12693969).
Has antimicrobial activity, which depends on the extracellular cation concentration (PubMed:6802759).
Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane (PubMed:14573629, PubMed:1599934, PubMed:6802759, PubMed:3169987, PubMed:11179314, PubMed:12693969).
Can also prevent bacterial biofilm development in P.aeruginosa infection (PubMed:12037568).
Has weak antifungal activity against C.albicans (PubMed:11083624).
Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth (PubMed:15166119).
Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection (PubMed:17079302).
Can inhibit papillomavirus infections (PubMed:17481742).
Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling (PubMed:20345905).
Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells (PubMed:19033648).
Stimulates VEGFA-mediated endothelial cell migration and proliferation (PubMed:16842782).
Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs) (PubMed:9359845).
Also binds specifically to pneumococcal surface protein A (PspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA (PubMed:9359845).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "LTF"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-003 | Recombinant Anti-human LTF VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
| HPAB-0194-YJ-VHH | Recombinant Camel Anti-LTF Single Domain Antibody (HPAB-0194-YJ-VHH) | ELISA, Immunoaffinity chromatography | Camel VHH |
| HPAB-0195-YJ-VHH | Recombinant Camel Anti-LTF Single Domain Antibody (HPAB-0195-YJ-VHH) | ELISA, Immunoaffinity chromatography | Camel VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0746MZ | Chicken Anti-Human Lactoferrin Polyclonal IgY | ELISA, ICC, IF, IHC, IP, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2100 | Hi-Affi™ Recombinant Rabbit Anti-LTF Monoclonal Antibody (DS2100AB) | ICC, IF, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0299-YJ-S(P) | Mouse Anti-LTF Recombinant Antibody (clone M-860); scFv Fragment | ELISA, Inhib, FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0299-YJ-F(E) | Mouse Anti-LTF Recombinant Antibody (clone M-860); Fab Fragment | ELISA, Inhib, FC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0523F | Mouse Anti-LTF Recombinant Antibody (clone 4C5) | FC, IF | Mouse IgG1 |
| ZG-0999F | Mouse Anti-LTF Recombinant Antibody (clone 67D9) | IHC-Fr, IHC-P, WB | Mouse IgG2a |
| VS3-WK779 | Mouse Anti-LTF Recombinant Antibody (clone Q100) | ELISA | Mouse IgG1 |
| VS3-WK1644 | Recombinant Mouse Anti-LTF Capture Antibody (clone 5B4) | ELISA | Mouse IgG1 |
| VS3-WK1645 | Recombinant Mouse Anti-LTF Detection Antibody (clone 9C1) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1277 | Anti-LTF Immunohistochemistry Kit | IHC | |
| VS-0525-XY4124 | Anti-Bovine LTF Immunohistochemistry Kit | IHC | |
| VS-0525-XY4123 | Anti-Human LTF Immunohistochemistry Kit | IHC |
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