Anti-LY75 (clone DEC-205) Recombinant Antibody Coupled Liposome (VS-1024-FY4)
CAT#: VS-1024-FY4
The Anti-LY75 Antibody Liposome is a cutting-edge delivery system engineered to specifically target and penetrate cells that express the LY75 receptor, which is predominantly located on antigen-presenting cells, particularly dendritic cells. By utilizing this specialized formulation, therapeutic agents can be effectively transported directly to the immune cells responsible for initiating and enhancing the immune response, thereby maximizing their therapeutic efficacy. This innovative approach not only improves the precision of drug delivery but also holds significant potential for enhancing the overall effectiveness of immunotherapies in treating various diseases, including cancer and infectious disorders.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line
Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human spleen
High expression. RNA expression: 18.4 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
Normal Tissue
Figure 4 IHC staining of human skeletal muscle
Low expression. RNA expression: 0.3 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, HDLM-2, Karpas-707, RT4, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
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More Infomation
Specifications
- Potential Clinical Applications
- Specific targeting of dendritic cells
Product Composition
- Clone
- DEC-205
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a humanized monoclonal antibody targeting the DEC-205 molecule on the surface of dendritic cells serves as a precise and effective carrier for antigens. This antibody facilitates the specific transport of antigens to antigen-presenting cells (APCs), promoting their internalization, processing, and presentation of the antigens. As a result, it enhances the antigen presentation efficiency of these cells, ultimately strengthening the body's immune response to the corresponding antigens.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- LY75
- Introduction
- Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).
- Alternative Names
- Neural Proliferation, Differentiation And Control 1; NPDC-1; Neural Proliferation Differentiation And Control Protein 1; CAB-1; CAB1; CAB-; CAB
- Full Name
- Neural Proliferation, Differentiation And Control 1
- Gene ID
- 56654
- UniProt ID
- Q9NQX5
- Cellular Localization
- Membrane
- Positive Control
- N-glycosylated. (O60449-LY75_HUMAN)
Glycosylation at Asn135, Asn345, Asn377, Asn529, Asn843, Asn865, Asn934, Asn1076, Asn1103, Asn1225, Asn1320, Asn1392, Asn1593, Asn1626, and Asn1642 (NX_O60449 [NX_O60449-1])
Modification sites at PhosphoSitePlus (O60449)
Glycosylation from GlyConnect LY75_HUMAN (1472)
Glycosylation from GlyGen (O60449) 21 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
- Post Translation Modifications
- Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity).
- Protein Refseq
- NP_002340.2
- Function
- Pneumonic Plague and Membranous Nephropathy
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone DEC-205"
- CAT
- Product Name
See other products for "LY75"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-637-F(E) | Recombinant Human Anti-human LY75 Antibody Fab Fragment | ELISA, WB, IP, FuncS | Fab |
| HPAB-0432LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0432LY-F(E)) | ELISA | Human Fab |
| HPAB-0433LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0433LY-F(E)) | ELISA | Human Fab |
| HPAB-0434LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0434LY-F(E)) | ELISA | Human Fab |
| HPAB-0435LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0435LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-637-S(P) | Recombinant Human Anti-human LY75 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| HPAB-0432LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0432LY-S(P)) | ELISA | Human scfv |
| HPAB-0433LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0433LY-S(P)) | ELISA | Human scfv |
| HPAB-0434LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0434LY-S(P)) | ELISA | Human scfv |
| HPAB-0435LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0435LY-S(P)) | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2105 | Hi-Affi™ Recombinant Rabbit Anti-LY75 Monoclonal Antibody (DS2105AB) | IHC-P, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0432LY | Human Anti-LY75 Recombinant Antibody (HPAB-0432LY) | ELISA | Human IgG1 |
| HPAB-0433LY | Human Anti-LY75 Recombinant Antibody (HPAB-0433LY) | ELISA | Human IgG1 |
| HPAB-0434LY | Human Anti-LY75 Recombinant Antibody (HPAB-0434LY) | ELISA | Human IgG1 |
| HPAB-0435LY | Human Anti-LY75 Recombinant Antibody (HPAB-0435LY) | ELISA | Human IgG1 |
| FAMAB-1616CQ | Rat Anti-LY75 Recombinant Antibody (clone NLDC145) | IB, FC, IF, IHC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY196 | Human Anti-LY75 scFv-Fc Chimera (VS-0325-FY196) | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC689 | Recombinant Anti-LY75 Vesicular Antibody, EV Displayed (VS-0425-YC689) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4139 | Anti-LY75 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4140 | Anti-Mouse LY75 Immunohistochemistry Kit | IHC |
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