Anti-LY75 (clone DEC-205) Recombinant Antibody Coupled Liposome (VS-1024-FY4) (CAT#: VS-1024-FY4)
The Anti-LY75 Antibody Liposome is a cutting-edge delivery system engineered to specifically target and penetrate cells that express the LY75 receptor, which is predominantly located on antigen-presenting cells, particularly dendritic cells. By utilizing this specialized formulation, therapeutic agents can be effectively transported directly to the immune cells responsible for initiating and enhancing the immune response, thereby maximizing their therapeutic efficacy. This innovative approach not only improves the precision of drug delivery but also holds significant potential for enhancing the overall effectiveness of immunotherapies in treating various diseases, including cancer and infectious disorders.
More Infomation
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
(Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
Figure 3 IHC staining of human spleen
(High expression. RNA expression: 18.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
(High expression. RNA expression: 18.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
Figure 4 IHC staining of human skeletal muscle
(Low expression. RNA expression: 0.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
(Low expression. RNA expression: 0.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
Figure 5 Cerebral cortex
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
Figure 6 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
Figure 7 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
Figure 8 Testis
(Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
(Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
Figure 9 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, HDLM-2, Karpas-707, RT4, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
Specifications
- Potential Clinical Applications
- Specific targeting of dendritic cells
Product Composition
- Clone
- DEC-205
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a humanized monoclonal antibody targeting the DEC-205 molecule on the surface of dendritic cells serves as a precise and effective carrier for antigens. This antibody facilitates the specific transport of antigens to antigen-presenting cells (APCs), promoting their internalization, processing, and presentation of the antigens. As a result, it enhances the antigen presentation efficiency of these cells, ultimately strengthening the body's immune response to the corresponding antigens.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- LY75
- Introduction
- Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).
- Alternative Names
- Neural Proliferation, Differentiation And Control 1; NPDC-1; Neural Proliferation Differentiation And Control Protein 1; CAB-1; CAB1; CAB-; CAB
- Full Name
- Neural Proliferation, Differentiation And Control 1
- Gene ID
- 56654
- UniProt ID
- Q9NQX5
- Cellular Localization
- Membrane
- Positive Control
- N-glycosylated. (O60449-LY75_HUMAN)
Glycosylation at Asn135, Asn345, Asn377, Asn529, Asn843, Asn865, Asn934, Asn1076, Asn1103, Asn1225, Asn1320, Asn1392, Asn1593, Asn1626, and Asn1642 (NX_O60449 [NX_O60449-1])
Modification sites at PhosphoSitePlus (O60449)
Glycosylation from GlyConnect LY75_HUMAN (1472)
Glycosylation from GlyGen (O60449) 21 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
- Post Translation Modifications
- Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity).
- Protein Refseq
- NP_002340.2
- Function
- Pneumonic Plague and Membranous Nephropathy
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-637 | Recombinant Anti-human LY75 Antibody | WB, Dot, FuncS | IgG |
| MOB-079LC | Recombinant Mouse Anti-Bovine LY75 Antibody | FC | Mouse IgG |
| MRO-0948-CN | Recombinant Rabbit Anti-LY75 Monoclonal Antibody (JB87-35) | WB, IHC, IP | Rabbit IgG |
| HPAB-0470-YJ | Mouse Anti-LY75 Recombinant Antibody (HPAB-0470-YJ) | ELISA, IP, FuncS | Mouse IgG2a |
| HPAB-0471-YJ | Mouse Anti-LY75 Recombinant Antibody (HPAB-0471-YJ) | ELISA, IP, FuncS | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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