Recombinant Humanized Anti-M2 protein Antibody (h14C2) (CAT#: HPAB-AP732-YC)
Humanized recombinant monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibody has anti-viral activity and may be useful for inhibiting influenza virus replication and influenza infection.
Specific Inquiry
FC
Figure 1 Recognition of control 293 cells or 293 cells transfected with conM2 gene (induced or not induced) by 14C2, h14C2 murine minibody, and h14C2 human minibody by flow cytometry.
Murine secondary antibody controls are represented with dashed lines and human secondary antibody controls are represented with solid lines. Values in the upper right corners of each histogram indicate the mean fluorescent intensity of the peak.
Gabbard, J., Velappan, N., Di Niro, R., Schmidt, J., Jones, C. A., Tompkins, S. M., & Bradbury, A. R. M. (2009). A humanized anti-M2 scFv shows protective in vitro activity against influenza. Protein Engineering, Design & Selection, 22(3), 189-198.
WB
Figure 2 Western blot recognition of control 293 cells or 293 cells transfected with conM2 gene (induced).
Western blot lanes: (1) Marker; (2) 293 cells; (3) 293-conM2; (4) 293-conM2, Fixed.
Gabbard, J., Velappan, N., Di Niro, R., Schmidt, J., Jones, C. A., Tompkins, S. M., & Bradbury, A. R. M. (2009). A humanized anti-M2 scFv shows protective in vitro activity against influenza. Protein Engineering, Design & Selection, 22(3), 189-198.
ELISA
Figure 3 Recognition of control 293 cells (293) or 293 cells transfected with conM2 gene and induced (conM2) by cell-based ELISA.
(A) human minibody constructs; (B) murine minibody constructs.
Gabbard, J., Velappan, N., Di Niro, R., Schmidt, J., Jones, C. A., Tompkins, S. M., & Bradbury, A. R. M. (2009). A humanized anti-M2 scFv shows protective in vitro activity against influenza. Protein Engineering, Design & Selection, 22(3), 189-198.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- IAV
- Species Reactivity
- IAV
- Clone
- h14C2
- Applications
- FC, WB, ELISA, FC, Inhib
- Related Disease
- Influenza infection
Product Property
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles
Applications
- Application Notes
- The M2 protein antibody has been reported in applications of Flow Cytometry, Western Blot, Enzyme-linked Immunosorbent Assay, Flow Cytometry, Inhibition.
Target
- Alternative Names
- Matrix protein 2; Influenza A virus (IAV) matrix protein 2 (M2)
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-226 | Recombinant Mouse Anti-IAV M2 protein Antibody (mAb 65) | WB, ELISA, FuncS | IgG |
| MOB-1777CT | Recombinant Mouse anti-Respiratory Syncytial Virus M2 Monoclonal antibody (STW6I6) | ELISA, ICC/IF, IP, WB |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-226 | Recombinant Mouse Anti-IAV M2 protein Antibody scFv Fragment (mAb 65) | WB, ELISA, FuncS | scFv |
| HPAB-AP732-YC-S(P) | Recombinant Humanized Anti-M2 protein Antibody scFv Fragment (h14C2) | ELISA, FC, Inhib, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-226 | Recombinant Mouse Anti-IAV M2 protein Antibody Fab Fragment (mAb 65) | WB, ELISA, FuncS | Fab |
| HPAB-AP732-YC--F(E) | Recombinant Humanized Anti-M2 protein Antibody Fab Fragment (h14C2) | ELISA, FC, Inhib, WB | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-240CT | Anti-IAV M2 Recombinant Antibody (14C2) | WB | |
| MRO-240CT-S(P) | Anti-IAV M2 Recombinant Antibody scFv Fragment (14C2) | IF, ELISA | |
| MRO-240CT-F(E) | Anti-IAV M2 Recombinant Antibody Fab Fragment (14C2) | IF, ELISA |
MHC Tetramer for Other Applications
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0173 | APC-A*02:01/M2 (LMLGEFLKL) MHC Tetramer | FCM | |
| MHC-CN0174 | PE-A*02:01/M2 (LMLGEFLKL) MHC Tetramer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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