Mouse Anti-MAP3K11 Recombinant Antibody (clone 3D11) (CAT#: VS-0625-FY40)

The Mouse IgG2a kappa monoclonal antibody, clone 3D11, is designed for detecting human MAP3K11. Its immunogen is a recombinant human MAP3K11 protein fragment, with an epitope mapping to amino acids 741-847. With an approximate antigen size of 47.7 kDa, this antibody is applicable in Western Blot (1:500), ELISA, FuncS, and IHC, offering versatile detection capabilities.

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Custom Production

We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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We require custom production
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgG2a, kappa
  • Species Reactivity
  • Human
  • Clone
  • 3D11
  • Applications
  • Western Blot, ELISA, Functional Assay, Immunohistochemistry
  • Related Disease
  • Dementia and Gastric Cancer

Product Property

  • Purification
  • Purified with Protein A or G affinity chromatography
  • Purity
  • >90% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS, pH 7.4
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • Western Blot: 1:500
    Optimal dilutions for assays should be determined by the user.

Target

  • Alternative Names
  • Mitogen-Activated Protein Kinase Kinase Kinase 11; Src-Homology 3 Domain-Containing Proline-Rich Kinase; Mixed Lineage Kinase 3; EC 2.7.11.25; MLK3; PTK1; SPRK
  • Long Name
  • Mitogen-Activated Protein Kinase Kinase Kinase 11
  • Sequence Similarities
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  • Cellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Post Translation Modifications
  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
    Thr-277 is likely to be the main autophosphorylation site.
    Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.
  • Function
  • Activates the JUN N-terminal pathway.
    Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7.

Recommended Products

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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