Anti-MAP3K14 Antibody Prodrug, Protease Activated (VS-1025-YC91)
CAT#: VS-1025-YC91
The Anti-MAP3K14 Antibody Prodrug, Protease Activated (VS-1025-YC91) is an antibody prodrug comprised of a recombinant human antibody targeting human MAP3K14, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to MAP3K14 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to MAP3K14 effectively. MAP3K14, or NIK (NF-kappaB-inducing kinase), is a kinase that acts as an oncogene by driving the non-canonical NF-kappaB signaling pathway. Mutations or translocations that stabilize NIK activity are found in various lymphomas and leukemias. This chronic activation promotes B-cell survival and proliferation, contributing to malignancy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nucleoli fibrillar center, cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27270/254_H10_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27269/62044_A_5_2_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27269/62044_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27269/62044_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27269/62044_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Pachytene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27269/62044_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27269/62044_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (A549, U-251 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000006062-MAP3K14
❮
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human MAP3K14
- Target
- MAP3K14
- Species Reactivity
- Human
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This is an antibody capable of specifically binding the amino acid sequence of NF-&kgr B-inducing kinase (NIK) MAP3K14, used for treatment including malignant diseases and diseases associated with pathological immune responses, such as autoimmune, allergic, inflammatory, and transplantation-related diseases.
- Alternative Names
- MAP3K14; HS; NIK; HSNIK; FTDCR1B
- Gene ID
- 9020
- UniProt ID
- Q68D39
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Related Diseases
Endometrial Cancer
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MAP3K14"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0836CL | Anti-Human MAP3K14 Recombinant Antibody (NIK-81) | ELISA, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0836CL-S(P) | Anti-Human MAP3K14 Recombinant Antibody scFv Fragment (NIK-81) | ELISA, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0836CL-F(E) | Anti-Human MAP3K14 Recombinant Antibody Fab Fragment (NIK-81) | ELISA, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4655 | Hi-Affi™ Recombinant Rabbit Anti-MAP3K14 Monoclonal Antibody (TH168DS) | WB, IF, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS7-0425-WR342 | Mouse Anti-MAP3K14 Recombinant Antibody (clone 2G2B4) | IHC, FC | Mouse IgG1 |
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