Rabbit Anti-MAP3K2 Recombinant Antibody (clone E6)
CAT#: VS-0724-FY10
This is a rabbit monoclonal antibody that binds to the human MAP3K2 peptide-NPIFEKFGKGGTYP. The immunogen is a methylated peptide-KLH conjugate. The affinity of this clone for the methylated peptide is 0.90 nM.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21540/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human gallbladder
Immunohistochemical staining of human gallbladder shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21540/48792_A_5_4_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21540/48792_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21540/48792_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21540/48792_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21540/48792_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21540/48792_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169967-MAP3K2
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Specifications
- Immunogen
- The immunogen is methylated peptide-KLH conjugate.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human MAP3K2
- Species Reactivity
- Human
- Clone
- E6
- Applications
- Western Blot
- Related Disease
- Lung Cancer
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Mitogen-Activated Protein Kinase Kinase Kinase 2; MAPK/ERK Kinase Kinase 2; MAP/ERK Kinase Kinase 2; MEK Kinase 2; MEKK 2; MEKK2; EC 2.7.11.25; MAPKKK2; MEKK2B
- Gene ID
- 10746
- UniProt ID
- Q9Y2U5
- Long Name
- Mitogen-Activated Protein Kinase Kinase Kinase 2
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cytoplasm
Nucleus
- Post Translation Modifications
- Autophosphorylated
Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation
Ubiquitination at Lys602
Modification sites at PhosphoSitePlus
- Protein Refseq
- XP_047298945.1; XP_047298946.1; XP_047298947.1; XP_054196193.1; XP_054196194.1
- Function
- Component of a protein kinase signal transduction cascade.
Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity).
Plays a role in caveolae kiss-and-run dynamics.
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Related Diseases
Endometrial Cancer
Throid Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2139 | Hi-Affi™ Recombinant Rabbit Anti-MAP3K2 Monoclonal Antibody (DS2139AB) | FC, ICC, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4217 | Anti-MAP3K2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4218 | Anti-Mouse MAP3K2 Immunohistochemistry Kit | IHC |
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