Recombinant Anti-MAPT (AA 506-511 x AA 537-541) Biparatopic Antibody, Tandem scFv (Clone 19G10 x Clone 10H8)
CAT#: VS-0525-YC121
The Recombinant Anti-MAPT (AA 506-511 x AA 537-541) Biparatopic Antibody, Tandem scFv (Clone 19G10 x Clone 10H8) is a biparatopic antibody (bpAb) designed to bind two distinct MAPT epitopes. This bpAb incorporates a tandem scFv: the 19G10 scFv (targeting amino acids 506-511, PKSGDR) is N-terminally fused to the 10H8 scFv (specific for amino acids 537-541, TREPK).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line BJ
Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells
Staining:
Medium
Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
❮
❯
Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Mouse
- Specificity
- Human MAPT
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- 19G10
- Clone 2
- 10H8
- Epitope 1
- aa 506-511, PKSGDR
- Epitope 2
- aa 537-541, TREPK
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Microtubule Associated Protein Tau
Target
- Introduction
- The microtubule-associated protein tau (MAPT)'s transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
- Alternative Names
- TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103; microtubule-associated protein tau; G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; microtubule-associated protein tau, isoform 4; neurofibrillary tangle protein; paired helical filament-tau; protein phosphatase 1, regulatory subunit 103
- Gene ID
- 4137
- UniProt ID
- P10636
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC120 | Recombinant Anti-MAPT (AA 220-224 x AA 506-511) Biparatopic Antibody, Tandem scFv (Clone 13A6 x Clone 19G10) | ELISA | Tandem scFv |
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