Rabbit Anti-MAPT Recombinant Antibody (clone Otau(S400)) (CAT#: HPAB-0108-WJ)
This product is a rabbit antibody targeting O-linked N-acetylglucosamine (O-GlcNAcylated) tau isoform 2N4R at serine 400. This antibody showed high binding affinity for a tau peptide O-GlcNAc modified at Ser400.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
Figure 2 IF staining of human cell line BJ
(Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
(Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
Figure 3 Cerebral cortex
(Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
(Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
Figure 4 Colon
(Endocrine cells
Staining:
Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
(Endocrine cells
Staining:
Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
Figure 5 Kidney
(Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
(Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
Specifications
- Immunogen
- Peptide (cVYKSPVV-(O-GlcNAc)S-GDTSPRH) corresponding to amino acids 393 to 407 on 2N4R human tau
- Host Species
- Rabbit
- Type
- Human IgG
- Specificity
- Human MAPT
- Species Reactivity
- Human
- Clone
- Otau(S400)
- Applications
- ELISA, WB
- Related Disease
- Alzheimer's Disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The MAPT antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Western Blot.
Target
- Alternative Names
- MAPT; PPP1R103; MTBT2; DDPAC; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; MTBT1; PHF-Tau; FTDP-17
- Gene ID
- 4137
- UniProt ID
- P10636
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-305 | Chicken Anti-MAPT Recombinant Antibody; Fab Fragment | WB, ELISA, FuncS | Chicken Fab |
| HPAB-0196-YJ-F(E) | Mouse Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-0196-YJ-F(E)) | ELISA | Mouse Fab |
| HPAB-0197-YJ-F(E) | Mouse Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-0197-YJ-F(E)) | ELISA | Mouse Fab |
| HPAB-0106-WJ-F(E) | Human Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-0106-WJ-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-0108-WJ-F(E) | Rabbit Anti-MAPT Recombinant Antibody (clone Otau(S400)); Fab Fragment | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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