Human Anti-MAPT Recombinant Antibody (VS-0224-FY12) (CAT#: VS-0224-FY12)
This monoclonal IgG1 antibody targets extracellular amyloid-β plaques in the brain, similar to gantenerumab, bapineuzumab, and solanezumab. It is a recombinant antibody derived from patients with slow or absent cognitive decline.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
Figure 2 IF staining of human cell line BJ
(Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
(Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
Figure 3 Cerebral cortex
(Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
(Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
Figure 4 Colon
(Endocrine cells
Staining:
Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
(Endocrine cells
Staining:
Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
Figure 5 Kidney
(Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
(Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG1
- Specificity
- The antibod selectively binds to amyloid aggregates in both the oligomeric and fibrillar states.
- Species Reactivity
- Human
- Applications
- Western Blot, Immunohistochemistry, ELISA
- Conjugate
- Unconjugated
- Related Disease
- Alzheimer's disease, Pick's disease
Product Property
- Purity
- >95%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, pH 7.4
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Microtubule Associated Protein Tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Protein Phosphatase 1, Regulatory Subunit 103; Neurofibrillary Tangle Protein; Paired Helical Filament-Tau; PHF-Tau; MAPTL; MTBT1; TAU
- Gene ID
- 4137
- UniProt ID
- P10636
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-305 | Chicken Anti-MAPT Recombinant Antibody; scFv Fragment | WB, ELISA, FuncS | Chicken scFv |
| PSBL-340 | Mouse Anti-MAPT Recombinant Antibody (clone AT8); scFv Fragment | ELISA, FuncS | Mouse scFv |
| HPAB-0654YY-S(P) | Human Anti-MAPT Recombinant Antibody; scFv Fragment (HPAB-0654YY-S(P)) | Block, IHC | Humanized scFv |
| HPAB-0655YY-S(P) | Human Anti-MAPT Recombinant Antibody; scFv Fragment (HPAB-0655YY-S(P)) | Block, IHC | Humanized scFv |
| HPAB-0656YY-S(P) | Human Anti-MAPT Recombinant Antibody; scFv Fragment (HPAB-0656YY-S(P)) | Block, IHC | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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