Rabbit Anti-MEF2C Recombinant Antibody (clone R07-6W9) (CAT#: VS3-XY3427)
The recombinant rabbit antibody is specific for MEF2C (Myocyte enhancer factor 2C), which plays an essential role in hippocampal-dependent learning and memory. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. The antibody specifically reacts with human and rat MEF2C. It has been tested using Western Blot and Immunohistochemistry-Paraffin.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5533/if_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5533/if_selected.jpg
Figure 2 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_8_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_8_5.jpg
Figure 3 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_6_6.jpg
Figure 4 Skeletal muscle
(Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_2_6.jpg
(Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_2_6.jpg
Figure 5 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_8.jpg
Figure 6 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_9_5.jpg
Figure 7 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_3.jpg
Figure 8 RNA cell line category: Cell line enhanced (Daudi, HEL, Karpas-707, REH, WM-115)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081189-MEF2C
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081189-MEF2C
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat MEF2C
- Species Reactivity
- Human, Rat
- Clone
- R07-6W9
- Applications
- WB, IHC-P
- Related Disease
- Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
Target
- Alternative Names
- NEDHSIL; DEL5q14.3; C5DELq14.3
- Gene ID
- 4208
- UniProt ID
- Q06413
- Long Name
- Myocyte enhancer factor 2C
- Cellular Localization
- Nucleus, Cytoplasm, sarcoplasm
- Post Translation Modifications
- Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity.
Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
(Q06413-MEF2C_HUMAN)
Modification sites at PhosphoSitePlus (Q06413)
Modification sites at neXtProt (NX_Q06413)
Glycosylation from GlyGen (Q06413) 4 sites, 1 O-linked glycan (4 sites)
- Protein Refseq
- XP_011541698.1; XP_005248568.1
- Function
- Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes.
Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development.
Enhances transcriptional activation mediated by SOX18.
Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Mouse Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1921z | Mouse Anti-MEF2C Recombinant Antibody (clone 21G4) | WB, FC, ICC, IF, IHC | Mouse IgG2a |
| VS3-WK130 | Mouse Anti-MEF2C Recombinant Antibody (clone G2-H2) | WB, ELISA | Mouse IgG1 |
| VS3-XY1059 | Mouse Anti-MEF2C Recombinant Antibody (clone 6H2G2) | ELISA, WB, IHC, FC | Mouse IgG1 |
| VS13-YC721 | Rabbit Anti-MEF2C Recombinant Antibody (VS13-YC721) | WB, IHC-P, IHC-Fr, ICC, IF, ELISA | Rabbit IgG |
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