Rabbit Anti-MEF2C Recombinant Antibody (VS13-YC721) (CAT#: VS13-YC721)
The Rabbit Anti-MEF2C Recombinant Antibody is specific for human and rat MEF2C. MEF2C encodes a family protein for myogenesis, maintaining muscle cell differentiation, linked to cognitive disabilities and neurodevelopmental problems. Various splicing variants are characterized. The anti-MEF2C antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5533/if_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5533/if_selected.jpg
Figure 2 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_8_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_8_5.jpg
Figure 3 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_6_6.jpg
Figure 4 Skeletal muscle
(Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_2_6.jpg
(Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_2_6.jpg
Figure 5 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_8.jpg
Figure 6 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_9_5.jpg
Figure 7 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_3.jpg
Figure 8 RNA cell line category: Cell line enhanced (Daudi, HEL, Karpas-707, REH, WM-115)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081189-MEF2C
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081189-MEF2C
Specifications
- Immunogen
- Recombinant human MEF2C.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat MEF2C
- Species Reactivity
- Human, Rat
- Applications
- WB, IHC-P, IHC-Fr, ICC, IF, ELISA
- Conjugate
- NONE
- Related Disease
- Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Target
- Alternative Names
- Myocyte Enhancer Factor 2C; MADS Box Transcription Enhancer Factor 2, Polypeptide C; Myocyte-Specific Enhancer Factor 2C; C5DELq14.3; DEL5q14.3;
- Gene ID
- 4208
- UniProt ID
- Q06413
- Long Name
- Myocyte Enhancer Factor 2C
- Cellular Localization
- Nucleus; Cytoplasm; sarcoplasm
- Protein Refseq
- XP_011541698.1; XP_005248568.1
- Function
- Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes.
Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development.
Enhances transcriptional activation mediated by SOX18.
Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
Mouse Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1921z | Mouse Anti-MEF2C Recombinant Antibody (clone 21G4) | WB, FC, ICC, IF, IHC | Mouse IgG2a |
| VS3-WK130 | Mouse Anti-MEF2C Recombinant Antibody (clone G2-H2) | WB, ELISA | Mouse IgG1 |
| VS3-XY1059 | Mouse Anti-MEF2C Recombinant Antibody (clone 6H2G2) | ELISA, WB, IHC, FC | Mouse IgG1 |
| VS3-XY3427 | Rabbit Anti-MEF2C Recombinant Antibody (clone R07-6W9) | WB, IHC-P | Rabbit IgG |
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