Rabbit Anti-MEF2C Recombinant Antibody (VS13-YC721)
CAT#: VS13-YC721
The Rabbit Anti-MEF2C Recombinant Antibody is specific for human and rat MEF2C. MEF2C encodes a family protein for myogenesis, maintaining muscle cell differentiation, linked to cognitive disabilities and neurodevelopmental problems. Various splicing variants are characterized. The anti-MEF2C antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5533/if_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_6_6.jpg
Normal Tissue
Figure 4 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_2_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_8.jpg
Normal Tissue
Figure 6 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_9_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_3.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, HEL, Karpas-707, REH, WM-115)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081189-MEF2C
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Specifications
- Immunogen
- Recombinant human MEF2C.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat MEF2C
- Species Reactivity
- Human, Rat
- Applications
- WB, IHC-P, IHC-Fr, ICC, IF, ELISA
- Conjugate
- NONE
- Related Disease
- Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Target
- Alternative Names
- Myocyte Enhancer Factor 2C; MADS Box Transcription Enhancer Factor 2, Polypeptide C; Myocyte-Specific Enhancer Factor 2C; C5DELq14.3; DEL5q14.3;
- Gene ID
- 4208
- UniProt ID
- Q06413
- Long Name
- Myocyte Enhancer Factor 2C
- Cellular Localization
- Nucleus; Cytoplasm; sarcoplasm
- Protein Refseq
- XP_011541698.1; XP_005248568.1
- Function
- Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes.
Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development.
Enhances transcriptional activation mediated by SOX18.
Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "MEF2C"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1921z | Mouse Anti-MEF2C Recombinant Antibody (clone 21G4) | WB, FC, ICC, IF, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0760CL | Anti-Human MEF2C Recombinant Antibody (9949CB) | ELISA, WB, IF |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0760CL-S(P) | Anti-Human MEF2C Recombinant Antibody scFv Fragment (9949CB) | ELISA, WB, IF |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0760CL-F(E) | Anti-Human MEF2C Recombinant Antibody Fab Fragment (9949CB) | ELISA, WB, IF |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK130 | Mouse Anti-MEF2C Recombinant Antibody (clone G2-H2) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY1059 | Mouse Anti-MEF2C Recombinant Antibody (clone 6H2G2) | ELISA, WB, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY3427 | Rabbit Anti-MEF2C Recombinant Antibody (clone R07-6W9) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1329 | Anti-MEF2C Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4342 | Anti-Mouse MEF2C Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4343 | Anti-Rat MEF2C Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4341 | Anti-Human MEF2C Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC127 | Anti-MEF2C Antibody Prodrug, Protease Activated (VS-1025-YC127) | ISZ, Cyt, FuncS |
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