Recombinant Rhesus monkey Anti-MERS-CoV S1 Antibody (FIB-H1) (CAT#: PABC-317)
This product is a recombinant Rhesus monkey antibody that can recognize MERS-CoV S1. FIB-H1 antibody, and can specifically bind to MERS-CoV S protein and neutralize MERS-CoV infection.
Specific Inquiry
ELISA
Figure 1 Binding specificity
MAbs isolated from immunized NHPs and a MERS survivor were assayed by ELISA for binding to soluble receptor-binding domain (RBD) or S1 protein. S1-specific MAbs (in blue) bound only to S1.
Wang, L., Shi, W., Chappell, J. D., Joyce, M. G., Zhang, Y., Kanekiyo, M., ... & Corbett, K. S. (2018). Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on the Middle East respiratory syndrome coronavirus spike glycoprotein to avoid neutralization escape. Journal of virology, 92(10), e02002-17.
Neut
Figure 2 Neutralization potency
Neutralization activity was measured using a MERS-CoV EMC S-pseudotyped lentivirus neutralization assay.
Wang, L., Shi, W., Chappell, J. D., Joyce, M. G., Zhang, Y., Kanekiyo, M., ... & Corbett, K. S. (2018). Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on the Middle East respiratory syndrome coronavirus spike glycoprotein to avoid neutralization escape. Journal of virology, 92(10), e02002-17.
Specifications
- Host Species
- Rhesus monkey
- Type
- Rhesus monkey IgG
- Specificity
- MERS-CoV S1
- Species Reactivity
- HCoV-EMC
- Clone
- FIB-H1
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody FIB-H1 has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
The antibody can be diluted into 0.001-10 μg/mL for Enzyme-linked Immunosorbent Assay and neutralization.
Target
- Alternative Names
- HCoV-EMC S; MERS-CoV S Spike; HCoV-EMC Spike; MERS-CoV S
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone FIB-H1"
See other products for "MERS-CoV S1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2252CQ | Recombinant Mouse Anti-MERS-CoV S1 Antibody (IT-B7) | ELISA, IF, IP | Mouse antibody |
| MRO-0133YJ | Mouse Anti-MERS-CoV S1 Recombinant Antibody (clone CBS109) | ELISA, IP, IF | Mouse IgG1 |
| MRO-0134YJ | Mouse Anti-MERS-CoV S1 Recombinant Antibody (clone CBS110) | ELISA, IP, IF | Mouse IgG1 |
| MRO-0166YJ | Mouse Anti-MERS-CoV S1 Recombinant Antibody (clone CBS133) | ELISA, IF | Mouse IgG2a |
| MRO-0167YJ | Mouse Anti-MERS-CoV S1 Recombinant Antibody (clone CBS134) | ELISA, IF | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-316 | Monkey Anti-MERS-CoV S1 Recombinant Antibody; Fab Fragment (PFBC-316) | ELISA, Neut | Monkey Fab |
| PFBC-317 | Recombinant Rhesus monkey Anti-MERS-CoV S1 Antibody Fab Fragment (FIB-H1) | ELISA, Neut | Rhesus monkey Fab |
| PFBC-318 | Recombinant Rhesus monkey Anti-MERS-CoV S1 Antibody Fab Fragment (FIB-B2) | ELISA, Neut | Rhesus monkey Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-316 | Monkey Anti-MERS-CoV S1 Recombinant Antibody; scFv Fragment (PSBC-316) | ELISA, Neut | Monkey scFv |
| PSBC-317 | Recombinant Rhesus monkey Anti-MERS-CoV S1 Antibody scFv Fragment (FIB-H1) | ELISA, Neut | Rhesus monkey scFv |
| PSBC-318 | Recombinant Rhesus monkey Anti-MERS-CoV S1 Antibody scFv Fragment (FIB-B2) | ELISA, Neut | Rhesus monkey scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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