AbPlus™ Anti-MERS-CoV S1 Magnetic Beads (CBS109) (CAT#: VS-0424-XY186)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magrose bead (> 50 μmol/mL gel)

• Bead Ligand
• Anti-MERS-CoV S1 specific antibody (CBS109)

• Target
• MERS-CoV S1

• Immunogen
• DNA vaccine expressing S1 of the spike protein (MERS-CoV/EMC 2C/2012) (aa 18-725)

• Target Species
• MERS-CoV

• Antibody Clone
• CBS109

• Bead Capacity
• 20-30 mg/mL binding antibody

• Bead size
• 10-37 μm

• Stability
• pH 2-14

• Format
• 20% Suspension

• Buffer
• PBS, pH 7.4, with 1% BSA

• Preservative
• 0.03% Proclin 300

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

• Alternative Names
• MERS-CoV Spike protein S1; MERS-CoV; S1; MERS; MERS-CoV/EMC 2C/2012

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