Anti-MFAP3L (clone W24V147) Recombinant Antibody Coupled Liposome (VS-1024-FY147)
CAT#: VS-1024-FY147
Anti-MFAP3L antibody-conjugated liposomes have shown promising potential in targeting colorectal cancer by allowing for precise localization of MFAP3L expression within tumor tissues. This targeted approach minimizes collateral damage to surrounding healthy tissues, which is crucial in maintaining patients' quality of life during treatment. Moreover, by enhancing the delivery and effectiveness of chemotherapy drugs specifically to cancer cells, this method may significantly boost overall therapeutic outcomes and improve survival rates for patients battling colorectal cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62306/1396_H3_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/77490/169490_B_8_5.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/77490/169490_A_8_4.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/77490/169490_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HMC-1, RT4, SK-BR-3, SuSa)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198948-MFAP3L
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More Infomation
Specifications
- Potential Clinical Applications
- Colorectal cancer
Product Composition
- Clone
- W24V147
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically engineered to target the protein MFAP3L (Microfibril Associated Protein 3 Like). This innovative therapeutic antibody is designed using advanced genetic and molecular techniques to ensure high specificity and affinity for the MFAP3L antigen.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MFAP3L
- Alternative Names
- MFAP3L; Human MFAP3L
- Full Name
- Microfibril Associated Protein 3 Like
- Gene ID
- 9848
- UniProt ID
- O75121
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein; Nucleus; Cytoplasm
- Post Translation Modifications
- Glycosylation at Asn111, Asn135, Asn33, Asn37, and Asn67 ( NX_O75121 [NX_O75121-1] )
Modification sites at PhosphoSitePlus ( O75121 )
Glycosylation from GlyGen (O75121) 6 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_005263423.1; XP_016864353.1; XP_016864354.1; XP_016864355.1; XP_016864356.1
- Function
- May participate in the nuclear signaling of EGFR and MAPK1/ERK2.
May a have a role in metastasis.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1154MZ | Recombinant Mouse Anti-Human MFAP3L Antibody (clone 5) | ELISA, WB | Mouse antibody |
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