Anti-MGMT (clone W24V110) Recombinant Antibody Coupled Liposome (VS-1024-FY112)
CAT#: VS-1024-FY112
Anti-MGMT antibody-conjugated liposomes have emerged as a promising therapeutic strategy for targeting gliomas, a notoriously difficult type of brain tumor. These innovative liposomal formulations can enhance drug delivery directly to tumor cells while minimizing collateral damage to healthy tissues, thereby improving treatment efficacy. Recent studies have highlighted the potential of these liposome-based nanomaterials, suggesting they could pave the way for novel approaches in glioma research and development, ultimately leading to more effective clinical treatments.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32135/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32136/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows nuclear positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69881/157873_A_5_2_selected.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69881/157873_A_6_6.jpg
Normal Tissue
Figure 5 Fallopian tube
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69881/157873_A_7_7.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69881/157873_A_7_8.jpg
Normal Tissue
Figure 7 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69881/157873_B_9_5.jpg
Normal Tissue
Figure 8 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69881/157873_A_7_3.jpg
Normal Tissue
Figure 9 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69881/157873_A_9_5.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (MCF7)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000170430-MGMT
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V110
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody designed to specifically target human MGMT (O6-methylguanine-DNA methyltransferase). Its unique structure allows for high affinity binding to the MGMT protein, making it an effective tool for various research applications, including cancer studies where MGMT plays a critical role in DNA repair mechanisms. By utilizing this antibody, researchers can gain deeper insights into MGMT's function and its implications in tumor resistance to alkylating agents, ultimately advancing our understanding of cancer therapies.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MGMT
- Introduction
- Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.
- Alternative Names
- O-6-Methylguanine-DNA Methyltransferase; Methylated-DNA--Protein-Cysteine Methyltransferase; -O-Methylguanine-DNA Methyltransferase; O-6-Methylguanine-DNA-Alkyltransferase; EC 2.1.1.63; O6-Methylguanine-DNA Methyltransferase; Methylguanine-DNA Methyltransferase
- Full Name
- O-6-Methylguanine-DNA Methyltransferase
- Gene ID
- 4255
- UniProt ID
- P16455
- Sequence Similarities
- Belongs to the MGMT family.
- Cellular Localization
- Nucleus
- Protein Refseq
- NP_002403.2
- Function
- Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
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COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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