Human Anti-MICA Recombinant Antibody (clone mAb1) (CAT#: HPAB-M0278-YC)
Provided is an antibody capable of binding to human MICA polypeptides. The antibody has increased activity in the treatment of disorders characterized by MICA-expressing cells, particularly cancer. mAb1 and mAb2 showed a particularly strong improvement in binding affinity for MICA alleles *01, *04 and *07.
Specific Inquiry
FuncS
Figure 1 shows that anti-MICA mAb1 induced specific lysis of C1R-MICA*008 cells.
FuncS
Figure 2 shows that anti-MICA mAb1 caused a strong increase in NK cell activation towards the 721.221-MICA*001 tumor cells.
FuncS
Figure 3 shows that while mice receiving isotype control or 1 μg anti-MICA antibody mAb1 did not survive at 100 days post injection.
FuncS
Figure 4 mice receiving anti-MICA antibody mAb1.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human MICA
- Species Reactivity
- Human
- Clone
- mAb1
- Applications
- FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
- Alternative Names
- MHC Class I Polypeptide-Related Sequence A; PERB11.1; MIC-A; Truncated MHC Class I Polypeptide-Related Sequence A; MHC Class I Chain-Related Protein A; Stress Inducible Class I Homolog; MHC Class I Related Sequence A; MHC Class I Related Chain A; HLA Class I Antigen;
- Gene ID
- 100507436
- UniProt ID
- Q29983
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1746-sdAb | Recombinant Anti-Human MICA VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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