Human Anti-MICA Recombinant Antibody (clone mAb1) (CAT#: HPAB-M0278-YC)
Provided is an antibody capable of binding to human MICA polypeptides. The antibody has increased activity in the treatment of disorders characterized by MICA-expressing cells, particularly cancer. mAb1 and mAb2 showed a particularly strong improvement in binding affinity for MICA alleles *01, *04 and *07.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FuncS
Figure 1 shows that anti-MICA mAb1 induced specific lysis of C1R-MICA*008 cells.
FuncS
Figure 2 shows that anti-MICA mAb1 caused a strong increase in NK cell activation towards the 721.221-MICA*001 tumor cells.
FuncS
Figure 3 shows that while mice receiving isotype control or 1 μg anti-MICA antibody mAb1 did not survive at 100 days post injection.
FuncS
Figure 4 mice receiving anti-MICA antibody mAb1.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human MICA
- Species Reactivity
- Human
- Clone
- mAb1
- Applications
- FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
- Alternative Names
- MHC Class I Polypeptide-Related Sequence A; PERB11.1; MIC-A; Truncated MHC Class I Polypeptide-Related Sequence A; MHC Class I Chain-Related Protein A; Stress Inducible Class I Homolog; MHC Class I Related Sequence A; MHC Class I Related Chain A; HLA Class I Antigen;
- Gene ID
- 100507436
- UniProt ID
- Q29983
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1746-sdAb | Recombinant Anti-Human MICA VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
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