Anti-MKI67 (clone W24V64) Recombinant Antibody Coupled Liposome (VS-1024-FY65) (CAT#: VS-1024-FY65)

• Potential Clinical Applications
• Breast cancer, Melanoma

• Clone
• W24V64

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• The recombinant mouse antibody exhibits a high degree of specificity in binding to human MKI67, a protein that plays a crucial role in cell proliferation and is often used as a marker for cell division. This antibody was engineered using advanced recombinant DNA techniques, allowing it to uniquely recognize and attach to the MKI67 protein present in human cells.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• MKI67

• Introduction
• This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.

• Alternative Names
• Marker Of Proliferation Ki-67; Antigen Identified By Monoclonal Antibody Ki-67; Protein Phosphatase 1, Regulatory Subunit 105; Antigen KI-67; Antigen Ki67; Proliferation-Related Ki-67 Antigen

• Full Name
• Marker Of Proliferation Ki-67

• Gene ID
• 4288

• UniProt ID
• P46013

• Cellular Localization
• Chromosome, Nucleus

• Post Translation Modifications
• Phosphorylated. Hyperphosphorylated in mitosis (PubMed:10502411, PubMed:10653604).
  Hyperphosphorylated form does not bind DNA.

• Protein Refseq
• NP_001139438.1; NP_002408.3

• Function
• Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226).
  Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226).
  Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226).
  Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551).
  Does not contribute to the internal structure of mitotic chromosomes (By similarity).
  May play a role in chromatin organization (PubMed:24867636).
  It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

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