Anti-MKI67 (clone W24V64) Recombinant Antibody Coupled Liposome (VS-1024-FY65)
CAT#: VS-1024-FY65
The application of anti-MKI67 antibody-conjugated liposomes in breast cancer represents a research strategy aimed at utilizing MKI67 as a biomarker to enhance targeted therapy. MKI67 is a cell proliferation marker that has been extensively studied for its role in assessing tumor prognosis. By using liposomes conjugated with anti-MKI67 antibodies, it is possible to achieve more efficient drug delivery and precise targeting of cancer cells.
The use of anti-MKI67 antibody conjugated liposomes aims to selectively target rapidly proliferating melanoma cells. MKI67 is a well-known proliferation marker, and liposome conjugation allows for enhanced drug delivery to these active tumor cells. This targeted approach could significantly increase therapeutic efficacy while limiting impact on normal, non-dividing cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies & nucleoli rim.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1164/13_B8_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nucleoli rim.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58/952_H5_3_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & nucleoli rim.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1164/30_B1_1_red_green.jpg
Normal Tissue
Figure 4 Colon
Goblet cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58/155454_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58/155454_A_6_6.jpg
Normal Tissue
Figure 6 Skin
Cells in basal layer
Staining: Medium
Intensity: Strong
Quantity: <25%
Cells in spinous layer
Staining: Medium
Intensity: Strong
Quantity: <25%
Hair follicles
Staining: High
Intensity: Strong
Quantity: 75%-25%
Lymphocytes
Staining: High
Intensity: Strong
Sebaceous glands
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58/155454_B_7_1.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58/155454_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000148773-MKI67
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer, Melanoma
Product Composition
- Clone
- W24V64
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant mouse antibody exhibits a high degree of specificity in binding to human MKI67, a protein that plays a crucial role in cell proliferation and is often used as a marker for cell division. This antibody was engineered using advanced recombinant DNA techniques, allowing it to uniquely recognize and attach to the MKI67 protein present in human cells.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MKI67
- Introduction
- This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.
- Alternative Names
- Marker Of Proliferation Ki-67; Antigen Identified By Monoclonal Antibody Ki-67; Protein Phosphatase 1, Regulatory Subunit 105; Antigen KI-67; Antigen Ki67; Proliferation-Related Ki-67 Antigen
- Full Name
- Marker Of Proliferation Ki-67
- Gene ID
- 4288
- UniProt ID
- P46013
- Cellular Localization
- Chromosome, Nucleus
- Post Translation Modifications
- Phosphorylated. Hyperphosphorylated in mitosis (PubMed:10502411, PubMed:10653604).
Hyperphosphorylated form does not bind DNA.
- Protein Refseq
- NP_001139438.1; NP_002408.3
- Function
- Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226).
Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226).
Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226).
Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551).
Does not contribute to the internal structure of mitotic chromosomes (By similarity).
May play a role in chromatin organization (PubMed:24867636).
It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
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Datasheet
MSDS
COA
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See other products for "MKI67"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0003MZ | Recombinant Mouse Anti-Human MKI67 Antibody (clone Li-68) | ELISA | Mouse antibody |
| ZG-0599F | Mouse Anti-MKI67 Recombinant Antibody (clone MIB-1) | IHC-Fr, IHC-P | Mouse IgG1 |
| ZG-0403U | Mouse Anti-MKI67 Recombinant Antibody (clone M25-Y) | IHC-P | Mouse IgG |
| ZG-0404U | Rabbit Anti-MKI67 Recombinant Antibody (clone M17-I) | IHC-P | Rabbit IgG |
| VS-0725-YC211 | Rabbit Anti-MKI67 Recombinant Antibody | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2237 | Hi-Affi™ Recombinant Rabbit Anti-MKI67 Monoclonal Antibody (DS2237AB) | ELISA, WB, IHC | IgG |
| MOR-4638 | Hi-Affi™ Recombinant Rabbit Anti-MKI67 Monoclonal Antibody (TH151DS) | IF, ICC, FC, ChIP | IgG |
| MOR-0054-FY | Rabbit Anti-MKI67 Recombinant Antibody (clone AFY0025) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2357LY-F(E) | Mouse Anti-MKI67 Recombinant Antibody (clone 73043-24E8); Fab Fragment | IHC, ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2357LY-S(P) | Mouse Anti-MKI67 Recombinant Antibody (clone 73043-24E8); scfv Fragment | IHC, ELISA, WB | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC730 | CytoStream™ Rabbit Anti-MKI67 Recombinant Antibody (VS13-YC730) | IHC-P, IHC-Fr, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4403 | Anti-MKI67 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4404 | Anti-Mouse MKI67 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4405 | Anti-Rabbit MKI67 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4406 | Anti-Canine MKI67 Immunohistochemistry Kit | IHC |
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