Rabbit Anti-MME Recombinant Antibody (clone R08-3X7) (CAT#: VS3-XY3430)
The product is a recombinant rabbit antibody that recognizes MME (Membrane metalloendopeptidase), which catalyzes cleavage of bradykinin, substance P and neurotensin peptides. It is capable of binding to human, mouse and rat MME. It has been used in a variety of applications, such as Western Blot, Immunohistochemistry-Paraffin and Immunoprecipitation.
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Normal Tissue
RNA Expression
Figure 1 Duodenum
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
Figure 2 High expression in small intestine
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
Figure 3 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat MME
- Species Reactivity
- Human, Rat
- Clone
- R08-3X7
- Applications
- WB, IHC-P, IP
- Related Disease
- Spinocerebellar Ataxia 43; Charcot-Marie-Tooth Disease, Axonal, Type 2T
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IP: 1/20
Target
- Alternative Names
- NEP; SFE; CD10; CALLA; CMT2T; SCA43
- Gene ID
- 4311
- UniProt ID
- P08473
- Long Name
- Membrane metalloendopeptidase
- Sequence Similarities
- Belongs to the peptidase M13 family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Myristoylation is a determinant of membrane targeting.
Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
- Protein Refseq
- NP_000893.2; NP_009218.2; NP_009219.2
- Function
- Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids.
Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991).
Catalyzes cleavage of bradykinin, substance P and neurotensin peptides.
Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9.
Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)).
Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L033R | anti-MME immunotoxin SN5d (Fab)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L034R | anti-MME immunotoxin SN5d (IgG)-RTA | Cytotoxicity assay, Functional assay |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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