Rabbit Anti-MME Recombinant Antibody (clone R08-3X7)
CAT#: VS3-XY3430
The product is a recombinant rabbit antibody that recognizes MME (Membrane metalloendopeptidase), which catalyzes cleavage of bradykinin, substance P and neurotensin peptides. It is capable of binding to human, mouse and rat MME. It has been used in a variety of applications, such as Western Blot, Immunohistochemistry-Paraffin and Immunoprecipitation.
Gene Expression
Normal Tissue
Figure 1 Duodenum
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
Normal Tissue
Figure 2 High expression in small intestine
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat MME
- Species Reactivity
- Human, Rat
- Clone
- R08-3X7
- Applications
- WB, IHC-P, IP
- Related Disease
- Spinocerebellar Ataxia 43; Charcot-Marie-Tooth Disease, Axonal, Type 2T
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IP: 1/20
Target
- Alternative Names
- NEP; SFE; CD10; CALLA; CMT2T; SCA43
- Gene ID
- 4311
- UniProt ID
- P08473
- Long Name
- Membrane metalloendopeptidase
- Sequence Similarities
- Belongs to the peptidase M13 family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Myristoylation is a determinant of membrane targeting.
Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
- Protein Refseq
- NP_000893.2; NP_009218.2; NP_009219.2
- Function
- Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids.
Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991).
Catalyzes cleavage of bradykinin, substance P and neurotensin peptides.
Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9.
Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)).
Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MME"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L033R | anti-MME immunotoxin SN5d (Fab)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L034R | anti-MME immunotoxin SN5d (IgG)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0276MZ | Recombinant Mouse Anti-Human Membrane Metallo-endopeptidase Antibody (clone 57D7) | IHC | Mouse antibody |
| MRO-1731-CN | Rabbit Anti-MME Polyclonal Antibody (MRO-1731-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-0244-FY | Recombinant Human Anti-MME Antibody | F | Human IgG1 |
| ZG-0075J | Mouse Anti-MME Recombinant Antibody (clone 5B8) | IF, ICC, IHC-P | Mouse IgG |
| VS11-QX104 | Mouse Anti-MME Recombinant Antibody (clone FR4D11) | FC, IF, IHC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2246 | Hi-Affi™ Recombinant Rabbit Anti-MME Monoclonal Antibody (DS2246AB) | ICC, IF, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244-FY-S(P) | Recombinant Human Anti-MME Antibody scFv Fragment | F | Human scFv |
| HPAB-0311-YJ-S(P) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); scFv Fragment | IHC, ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244-FY-F(E) | Recombinant Human Anti-MME Antibody Fab Fragment | F | Human Fab |
| HPAB-0311-YJ-F(E) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); Fab Fragment | IHC, ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY1083 | Mouse Anti-MME Recombinant Antibody (clone 307CT12.12.5) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC682 | AbPlus™ Anti-MME Magnetic Beads (VS-0724-YC682) | IP, Protein Purification | |
| VS-0724-YC779 | AbPlus™ Anti-MME Magnetic Beads (VS-0724-YC779) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC720 | Recombinant Anti-MME Vesicular Antibody, EV Displayed (VS-0425-YC720) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4431 | Anti-MME Immunohistochemistry Kit | IHC | |
| VS-0525-XY4432 | Anti-Mouse MME Immunohistochemistry Kit | IHC | |
| VS-0525-XY4433 | Anti-Rat MME Immunohistochemistry Kit | IHC |
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