AbPlus™ Anti-MSH6 Magnetic Beads (JA84-26) (CAT#: VS-0424-XY189)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magrose bead (> 50 μmol/mL gel)

• Bead Ligand
• Anti-MSH6 specific antibody (JA84-26)

• Target
• MSH6

• Immunogen
• C-terminus of human MSH6

• Target Species
• Human, Mouse

• Antibody Clone
• JA84-26

• Bead Capacity
• 20-30 mg/mL binding antibody

• Bead size
• 10-37 μm

• Stability
• pH 2-14

• Format
• 20% Suspension

• Buffer
• PBS, pH 7.4, with 1% BSA

• Preservative
• 0.03% Proclin 300

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

• Alternative Names
• MutS Homolog 6; G/T Mismatch-Binding Protein; MutS-Alpha 160 KDa Subunit; MutS Protein Homolog 6; GTMBP; GTBP; P160; DNA Mismatch Repair Protein Msh6

• Gene ID
• 2956

• UniProt ID
• P52701

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